D
Derville O'Shea
Researcher at Imperial College London
Publications - 4
Citations - 226
Derville O'Shea is an academic researcher from Imperial College London. The author has contributed to research in topics: Transplantation & Autologous stem-cell transplantation. The author has an hindex of 4, co-authored 4 publications receiving 216 citations. Previous affiliations of Derville O'Shea include Hammersmith Hospital.
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Journal ArticleDOI
Predictive factors for survival in myeloma patients who undergo autologous stem cell transplantation: a single-centre experience in 211 patients
Derville O'Shea,Chrissy Giles,Evangelos Terpos,Jolanta B. Perz,Marianna Politou,V Sana,Kikkeri N. Naresh,Irvin A. Lampert,Diana Samson,S Narat,Edward Kanfer,Eduardo Olavarria,J. F. Apperley,Amin Rahemtulla +13 more
TL;DR: It is concluded that ASCT is safe and effective and the outcome is independent of age, time from diagnosis, previous treatment and conditioning regimen and the international prognostic index at transplant.
Journal ArticleDOI
Posttransplantation imatinib as a strategy to postpone the requirement for immunotherapy in patients undergoing reduced-intensity allografts for chronic myeloid leukemia.
Eduardo Olavarria,Shamyla Siddique,Mike Griffiths,Sharon Avery,Jenny Byrne,Karen Piper,Anne Lennard,Lalit Pallan,Julie Arrazi,Jolanta B. Perz,Derville O'Shea,John M. Goldman,Jane F. Apperley,Charles Craddock +13 more
TL;DR: Adjunctive targeted therapy allows the kinetics of disease relapse after a reduced-intensity allograft to be manipulated and represents a novel strategy by which outcome may be improved in patients who undergo transplantation for CML and other leukemias.
Journal ArticleDOI
LACE-conditioned autologous stem cell transplantation for relapsed or refractory Hodgkin's lymphoma: treatment outcome and risk factor analysis in 67 patients from a single centre
Jolanta B. Perz,Chrissy Giles,Richard Szydlo,Derville O'Shea,Jaime Sanz,Aristeidis Chaidos,Simon D. Wagner,John C. Davis,Sandra Loaiza,Deborah B. Marin,J. F. Apperley,Eduardo Olavarria,Amin Rahemtulla,Irvin A. Lampert,Kikkeri N. Naresh,Diana Samson,Donald Macdonald,Edward Kanfer +17 more
TL;DR: Mixed cellularity classical or lymphocyte-depleted classical histology subtype and haemoglobin level of 10 g/dl or less at the time of ASCT were identified as risk factors for worse OS, whereas stage III or IV disease at diagnosis and disease status at ASCT predicted inferior PFS.
Journal ArticleDOI
Impact of HLA class I and class II DNA high-resolution HLA typing on clinical outcome in adult unrelated stem cell transplantation after in vivo T-cell depletion with alemtuzumab.
Jolanta B. Perz,Richard Szydlo,Ruhena Sergeant,Jaime Sanz,Derville O'Shea,Thahmina Khan,Nick J. Davey,Sandra Loaiza,John C. Davis,Jane F. Apperley,Eduardo Olavarria +10 more
TL;DR: In univariate analysis the disease risk group and CMV seronegativity of recipient and donor were the only significant predictors for survival, with 3-year survival probabilities of 71.2% for CML-CP1 and 28% for poor risk diseases.