D
Desirée L. Salazar
Researcher at University of California, Irvine
Publications - 9
Citations - 1746
Desirée L. Salazar is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Neural stem cell & Spinal cord injury. The author has an hindex of 8, co-authored 9 publications receiving 1583 citations. Previous affiliations of Desirée L. Salazar include San Diego State University & University of California, San Diego.
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Journal ArticleDOI
Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice
Brian J. Cummings,Nobuko Uchida,Stanley Tamaki,Desirée L. Salazar,Mitra J. Hooshmand,Robert L. Summers,Fred H. Gage,Aileen J. Anderson +7 more
TL;DR: It is reported that prospectively isolated, human CNS stem cells grown as neurospheres (hCNS-SCns) survive, migrate, and express differentiation markers for neurons and oligodendrocytes after long-term engraftment in spinal cord-injured NOD-scid mice.
Journal ArticleDOI
Quantitative analysis of cellular inflammation after traumatic spinal cord injury: Evidence for a multiphasic inflammatory response in the acute to chronic environment
Kevin D. Beck,Hal X. Nguyen,Manuel D. Galvan,Desirée L. Salazar,Trent M. Woodruff,Aileen J. Anderson +5 more
TL;DR: The present study characterizes a novel cell preparation method that assesses, quickly and effectively, the changes in the principal immune cell types by flow cytometry in the injured spinal cord, daily for the first 10 days and periodically up to 180 days after spinal cord injury, to identify a surprising and extended multiphasic response of cellular inflammation.
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Human neural stem cells differentiate and promote locomotor recovery in an early chronic spinal cord injury NOD-scid mouse model.
TL;DR: The results suggest that hCNS-SCns are capable of surviving, differentiating, and promoting improved locomotor recovery when transplanted into an early chronic injury microenvironment and expands the “window of opportunity” for intervention.
Journal ArticleDOI
Therapeutic AAV9-mediated Suppression of Mutant SOD1 Slows Disease Progression and Extends Survival in Models of Inherited ALS
Kevin D. Foust,Desirée L. Salazar,Desirée L. Salazar,Desirée L. Salazar,Shibi Likhite,Shibi Likhite,Laura Ferraiuolo,Dara Ditsworth,Hristelina Ilieva,Kathrin Meyer,Leah Schmelzer,Lyndsey Braun,Don W. Cleveland,Don W. Cleveland,Brian K. Kaspar,Brian K. Kaspar +15 more
TL;DR: Slow disease onset and progression in two mouse models are reported following therapeutic delivery using a single peripheral injection of an adeno-associated virus serotype 9 (AAV9) encoding an shRNA to reduce the synthesis of ALS-causing human SOD1 mutants.
Journal ArticleDOI
Safety of Human Neural Stem Cell Transplantation in Chronic Spinal Cord Injury
Katja M. Piltti,Desirée L. Salazar,Desirée L. Salazar,Nobuko Uchida,Brian J. Cummings,Aileen J. Anderson +5 more
TL;DR: The data suggest chronic transplantation may have enhanced the generation of mature oligodendrocytes and the timing of transplantation did not induce changes in allodynia or hyperalgesia measures, and support the safety of hCNS‐SCns transplantation in the chronic period post‐SCI.