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Robert L. Summers
Researcher at Australian National University
Publications - 22
Citations - 1310
Robert L. Summers is an academic researcher from Australian National University. The author has contributed to research in topics: Plasmodium falciparum & Chloroquine. The author has an hindex of 14, co-authored 21 publications receiving 1149 citations. Previous affiliations of Robert L. Summers include Harvard University.
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Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice
Brian J. Cummings,Nobuko Uchida,Stanley Tamaki,Desirée L. Salazar,Mitra J. Hooshmand,Robert L. Summers,Fred H. Gage,Aileen J. Anderson +7 more
TL;DR: It is reported that prospectively isolated, human CNS stem cells grown as neurospheres (hCNS-SCns) survive, migrate, and express differentiation markers for neurons and oligodendrocytes after long-term engraftment in spinal cord-injured NOD-scid mice.
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Know your enemy: understanding the role of PfCRT in drug resistance could lead to new antimalarial tactics
TL;DR: It is suggested that PfCRT can be viewed both as a ‘multidrug-resistance carrier’ and as a drug target, and that the quinoline-res resistance mechanism is a potential ‘Achilles’ heel’ of the parasite.
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Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite’s chloroquine resistance transporter
Robert L. Summers,Anurag Dave,Tegan J. Dolstra,Sebastiano Bellanca,Rosa V. Marchetti,Megan N. Nash,Sashika N. Richards,Valerie Goh,Robyn L. Schenk,Wilfred D. Stein,Kiaran Kirk,Cecilia P. Sanchez,Michael Lanzer,Rowena E. Martin +13 more
TL;DR: The finding that diverse forms of mutant PfCRT variants are all limited in their capacity to transport CQ suggests that resistance could be overcome by reoptimizing the CQ dosage.
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Quinoline antimalarials containing a dibemethin group are active against chloroquinone-resistant Plasmodium falciparum and inhibit chloroquine transport via the P. falciparum chloroquine-resistance transporter (PfCRT).
Vincent K. Zishiri,Mukesh C. Joshi,Roger Hunter,Kelly Chibale,Pete Smith,Robert L. Summers,Rowena E. Martin,Timothy J. Egan +7 more
TL;DR: A series of 4-amino-7-chloroquinolines with dibenzylmethylamine (dibemethin) side chains were shown to inhibit synthetic hemozoin formation, the first example of a dual-function antimalarial for which the ability to inhibit both hemozosin formation and PfCRT has been demonstrated directly.
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Mimicking the intramolecular hydrogen bond: Synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents
Sandra Gemma,Sandra Gemma,Caterina Camodeca,Caterina Camodeca,Margherita Brindisi,Margherita Brindisi,Simone Brogi,Simone Brogi,Gagan Kukreja,Gagan Kukreja,Sanil Kunjir,Sanil Kunjir,Emanuele Gabellieri,Emanuele Gabellieri,Leonardo Lucantoni,Leonardo Lucantoni,Annette Habluetzel,Annette Habluetzel,Donatella Taramelli,Donatella Taramelli,Nicoletta Basilico,Nicoletta Basilico,Roberta Gualdani,Francesco Tadini-Buoninsegni,Gianluca Bartolommei,Maria Rosa Moncelli,Rowena E. Martin,Robert L. Summers,Stefania Lamponi,Stefania Lamponi,Luisa Savini,Luisa Savini,Isabella Fiorini,Isabella Fiorini,Massimo Valoti,Ettore Novellino,Ettore Novellino,Giuseppe Campiani,Giuseppe Campiani,Stefania Butini,Stefania Butini +40 more
TL;DR: Compound 6c emerged from this work as the most promising analogue of the series; it possessed low toxicity and good antimalarial activity when administered orally to P. berghei -infected mice.