D
Desmond N. Carney
Researcher at Mater Misericordiae University Hospital
Publications - 182
Citations - 15185
Desmond N. Carney is an academic researcher from Mater Misericordiae University Hospital. The author has contributed to research in topics: Lung cancer & Cancer. The author has an hindex of 57, co-authored 182 publications receiving 14854 citations. Previous affiliations of Desmond N. Carney include United States Department of Veterans Affairs & George Washington University.
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Journal ArticleDOI
Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer.
Frank Cuttitta,Desmond N. Carney,James L. Mulshine,Terry W. Moody,Joseph Fedorko,Adam Fischler,John D. Minna +6 more
TL;DR: It is demonstrated that a monoclonal antibody to bombesin binds to the C-terminal region of BLPs, blocks the binding of the hormone to cellular receptors and inhibits the clonal growth of SCLC in vitro and the growth ofSCLC xenografts in vivo.
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Amplification and expression of the c- myc oncogene in human lung cancer cell lines
TL;DR: In this article, the amplification and expression of the c-myc oncogene in a system other than B-cell lymphomas, namely human lung cancer, was reported.
Journal Article
Establishment and Identification of Small Cell Lung Cancer Cell Lines Having Classic and Variant Features
Desmond N. Carney,Adi F. Gazdar,Gerold Bepler,John G. Guccion,Paul J. Marangos,Terry W. Moody,Mark H. Zweig,John D. Minna +7 more
TL;DR: Using a chemically defined medium containing hydrocortisone, insulin, transferrin, 17 beta-estradiol and selenium, with or without serum supplementation, continuous cell lines can be established from 72% of all fresh biopsy specimens of small cell lung cancer containing tumor cells.
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Taxanes, microtubules and chemoresistant breast cancer.
TL;DR: Overexpression of the drug efflux pump MDR-1/P-gp, altered expression of microtubule-associated proteins (MAPs) including tau, stathmin and MAP4 may help to identify those patients who are most at risk of recurrence and those patients most likely to benefit from taxane treatment.
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High levels of intracellular bombesin characterize human small-cell lung carcinoma.
TL;DR: "Small cells" or "oat cells" characterize a virulent form of lung cancer and share many biochemical properties with peptide-secreting neurones, suggesting that bombesinergic precursor cells in lung may give rise to this disease.