T
Terry W. Moody
Researcher at National Institutes of Health
Publications - 273
Citations - 14737
Terry W. Moody is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Receptor & Bombesin. The author has an hindex of 60, co-authored 266 publications receiving 14240 citations. Previous affiliations of Terry W. Moody include Washington University in St. Louis & Albert Einstein College of Medicine.
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Journal ArticleDOI
Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer.
Frank Cuttitta,Desmond N. Carney,James L. Mulshine,Terry W. Moody,Joseph Fedorko,Adam Fischler,John D. Minna +6 more
TL;DR: It is demonstrated that a monoclonal antibody to bombesin binds to the C-terminal region of BLPs, blocks the binding of the hormone to cellular receptors and inhibits the clonal growth of SCLC in vitro and the growth ofSCLC xenografts in vivo.
Journal Article
Establishment and Identification of Small Cell Lung Cancer Cell Lines Having Classic and Variant Features
Desmond N. Carney,Adi F. Gazdar,Gerold Bepler,John G. Guccion,Paul J. Marangos,Terry W. Moody,Mark H. Zweig,John D. Minna +7 more
TL;DR: Using a chemically defined medium containing hydrocortisone, insulin, transferrin, 17 beta-estradiol and selenium, with or without serum supplementation, continuous cell lines can be established from 72% of all fresh biopsy specimens of small cell lung cancer containing tumor cells.
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High levels of intracellular bombesin characterize human small-cell lung carcinoma.
TL;DR: "Small cells" or "oat cells" characterize a virulent form of lung cancer and share many biochemical properties with peptide-secreting neurones, suggesting that bombesinergic precursor cells in lung may give rise to this disease.
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Adrenomedullin expression in human tumor cell lines : its potential role as an autocrine growth factor
Mae Jean Miller,Alfredo Martínez,Edward J. Unsworth,Carol J. Thiele,Terry W. Moody,Theodore H. Elsasser,Frank Cuttitta +6 more
TL;DR: The collective data demonstrate that AM and AM receptor are expressed in numerous human cancer cell lines of diverse origin and constitute a potential autocrine growth mechanism that could drive neoplastic proliferation.
Journal Article
Selective stimulation of small cell lung cancer clonal growth by bombesin and gastrin-releasing peptide.
TL;DR: In this article, the effect of exogenously added BN and gastrinreleasing peptide (GRP) on the soft agarose colony growth of a panel of human cell lines was investigated.