Showing papers by "DeWitt S. Goodman published in 1983"
Journal Article•
TL;DR: It is postulated that this abnormal form of TTR selectively deposits in tissues as the amyloid characteristic of the disease.
Abstract: In summary, these studies have demonstrated the following: 1) plasma TTR levels are significantly decreased in Portuguese patients with FAP; 2) FAP-TTR is indistinguishable from normal TTR with regard to a wide range of physiochemical properties; 3) RBP levels and vitamin A transport appear to be normal in FAP patients; 4) an abnormal TTR with a methionine for valine substitution at position 30 is found as amyloid protein in tissues of patients with FAP; and 5) this abnormal TTR is present in small amounts in plasma of patients with FAP. Based on these observations, we postulate that this abnormal form of TTR selectively deposits in tissues as the amyloid characteristic of the disease.
98 citations
Journal Article•
TL;DR: Preliminary observations suggest that FAP patients do produce an abnormal form of TTR that selectively deposits in tissues as amyloid protein.
93 citations
TL;DR: Total body turnover of cholesterol was studied in two patients with abetalipoproteinemia, and the resulting specific activity-time curves were fitted with a three-pool model, suggesting general applicability of this model.
17 citations
TL;DR: The LDL molecule was observed in immediate contact with the receptor and the coated vesicle, indicating that receptor-ligand binding occurs by short-range interactions.
4 citations