S
Steven Birken
Researcher at Columbia University
Publications - 119
Citations - 5285
Steven Birken is an academic researcher from Columbia University. The author has contributed to research in topics: Human chorionic gonadotropin & Monoclonal antibody. The author has an hindex of 42, co-authored 119 publications receiving 5212 citations. Previous affiliations of Steven Birken include National Institutes of Health & Hunter College.
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Amyloid fibril protein in familial amyloidotic polyneuropathy, Portuguese type. Definition of molecular abnormality in transthyretin (prealbumin).
TL;DR: It is suggested that the variant TTR represents the specific biochemical cause of the disease, and that this abnormal form of TTR selectively deposits in tissues as the amyloid characteristic of the Alzheimer's disease.
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Molecular cloning and nucleotide sequence of the streptavidin gene
TL;DR: Using synthetic oligonucleotides as probes, the streptavidin gene is cloned from a genomic library of Streptomyces avidinii and the deduced amino acids sequence shows several interrupted blocks of homology with the amino acid sequence of chicken egg-white avidin.
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Evidence for a gonadotropin from nonpregnant subjects that has physical, immunological, and biological similarities to human chorionic gonadotropin
Hao-Chia Chen,Gary D. Hodgen,Shuji Matsu'ura,Lawrence J. Lin,Erhard Gross,Leo E. Reichert,Steven Birken,Robert E. Canfield,Griff T. Ross +8 more
TL;DR: Results indicate that fractions showing immunocrossreactivity with the antiserum to hCGbeta-carboxyl-terminal peptide coeluted with 125I-labeled hCG which was separated distinctly from hLH, without crossreactivity to human luteinizing hormone.
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Structure of the Human Chorionic Gonadotropin β-Subunit Fragment from Pregnancy Urine*
Steven Birken,Elmo G. Armstrong,Mary Ann Gawinowicz Kolks,Laurence A. Cole,Gladys Agosto,Alexander Krichevsky,Judith L. Vaitukaitis,Robert E. Canfield +7 more
TL;DR: A major portion of the hCG immunoreactivity detectable in pregnancy urine is derived from a fragment of hCG beta, which lacks the COOH-terminal portion of h CG beta, but retains immunore activity with most antibodies raised against the beta-subunit of hGD.
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Isolation and Characterization of Human Pituitary Chorionic Gonadotropin
Steven Birken,Yacov Maydelman,Mary Ann Gawinowicz,Andrew Pound,Youping Liu,Anne Stockell Hartree +5 more
TL;DR: Pituitary hCG was purified from acetone-preserved human pituitary glands using immunoaffinity chromatography using antibodies to the COOH-terminal region of hCGbeta and indicated that it was 50% as active as hCG purified from the urine of pregnant women in cAMP assays.