D
DeWitt S. Goodman
Researcher at Columbia University
Publications - 180
Citations - 16084
DeWitt S. Goodman is an academic researcher from Columbia University. The author has contributed to research in topics: Retinol & Retinol binding protein. The author has an hindex of 70, co-authored 180 publications receiving 15820 citations. Previous affiliations of DeWitt S. Goodman include Albert Einstein College of Medicine & Hoffmann-La Roche.
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Journal ArticleDOI
The Effects of Colestipol Resin and of Colestipol Plus Clofibrate on the Turnover of Plasma Cholesterol in Man
TL;DR: The findings suggest that the total body turnover of cholesterol is under close homeostatic control in an integrated manner and does not support the suggestion that clofibrate can block the increased rate of cholesterol synthesis and turnover resulting from bile acid-sequestrant treatment.
Journal Article
Distribution of transthyretin in the rat eye.
Andrew J. Dwork,T Cavallaro,Robert L. Martone,DeWitt S. Goodman,Eric A. Schon,Joseph Herbert +5 more
TL;DR: It is demonstrated by immunohistochemistry that TTR has a more widespread distribution in the rat eye than does its mRNA, and the findings suggest that ocular TTR is synthesized, at least in part, in the RPE and is transported to specific locations within the eye.
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Distribution and levels of cellular retinol- and cellular retinoic acid-binding protein in various types of rat testis cells.
TL;DR: The distribution and levels of cellular retinol-binding proteins (CRBP) and cellular retinoic acid-binding protein (CRABP) were measured in rat testicular peritubular and Sertoli cells.
Journal ArticleDOI
Comparison of the effects of vitamin A and its analogs upon rabbit ear cartilage in organ culture and upon growth of the vitamin A-deficient rat.
TL;DR: The alpha-ionone analogs of retinol and retinoic acid were able to maintain good health and growth of vitamin A-deficient rats, although their quantitative activity was low.
Journal ArticleDOI
Distributions of retinoids, retinoid-binding proteins and related parameters in different types of liver cells isolated from young and old rats
H.F.J. Hendriks,William S. Blaner,Herm M. Wennekers,Roseann Piantedosi,Adriaan Brouwer,A. Margreet de Leeuw,DeWitt S. Goodman,Dick Knook +7 more
TL;DR: No major changes occur in the retinoids-related parameters analyzed with age, suggesting that rat liver retinoid metabolism does not change dramatically with age and thatretinoid homeostasis is maintained.