Dharmaraj Chinnappan

TL;DR: It is shown that it is possible to disrupt, restore, and move loops and domains using targeted mutations as small as a single base pair at CTCF sites, and it is found that the observed contact domains are inconsistent with the equilibrium state for an ordinary condensed polymer.

TL;DR: In this article, the preadipocytes that fat cells develop from exhibit distinct regional characteristics that persist in culture, and human abdominal subcutaneous cultured pre-adipo...

TL;DR: Despite dividing 40 population doublings, hTERT strains derived from single preadipocytes retained fat depot–specific cell dynamic characteristics, consistent with heritable processes contributing to regional variation in fat tissue function.

TL;DR: Evidence is provided that Aurora-B is a short-lived protein degraded by the proteasome via the anaphase-promoting cyclosome complex (APC/c) pathway, and overexpression of a stable form of Aurora- B alone induces aneuploidy and anchorage-independent growth.

TL;DR: The data suggest that targeted DNA methylation silencing of ECAD and DAPK occurs in the early stages and that of p16 and MGMT in the later stages of lung cancer progression, and provides preliminary evidence that peripheral lymphocytes could potentially be used as a surrogate for bronchial epithelial cells to detect alteredDNA methylation in smokers.