M
Miriam H. Huntley
Researcher at Baylor College of Medicine
Publications - 24
Citations - 11025
Miriam H. Huntley is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 10, co-authored 19 publications receiving 8065 citations. Previous affiliations of Miriam H. Huntley include Massachusetts Institute of Technology & Harvard University.
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Journal ArticleDOI
A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping
Suhas S.P. Rao,Miriam H. Huntley,Neva C. Durand,Elena K. Stamenova,Ivan D. Bochkov,James T. Robinson,James T. Robinson,Adrian L. Sanborn,Ido Machol,Ido Machol,Arina D. Omer,Arina D. Omer,Eric S. Lander,Eric S. Lander,Eric S. Lander,Erez Lieberman Aiden +15 more
TL;DR: In situ Hi-C is used to probe the 3D architecture of genomes, constructing haploid and diploid maps of nine cell types, identifying ∼10,000 loops that frequently link promoters and enhancers, correlate with gene activation, and show conservation across cell types and species.
Journal ArticleDOI
Juicer provides a one-click system for analyzing loop-resolution Hi-C experiments
Neva C. Durand,Muhammad S. Shamim,Muhammad S. Shamim,Ido Machol,Ido Machol,Suhas S.P. Rao,Miriam H. Huntley,Eric S. Lander,Eric S. Lander,Erez Lieberman Aiden +9 more
TL;DR: Juicer as mentioned in this paper is an open-source tool for analyzing terabase-scale Hi-C datasets, which allows users without a computational background to transform raw sequence data into normalized contact maps with one click.
Journal ArticleDOI
Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes.
Adrian L. Sanborn,Adrian L. Sanborn,Adrian L. Sanborn,Suhas S.P. Rao,Suhas S.P. Rao,Su Chen Huang,Neva C. Durand,Miriam H. Huntley,Andrew I. Jewett,Ivan D. Bochkov,Dharmaraj Chinnappan,Ashok Cutkosky,Jian Li,Jian Li,Kristopher Geeting,Andreas Gnirke,Alexandre Melnikov,Doug McKenna,Elena K. Stamenova,Elena K. Stamenova,Eric S. Lander,Eric S. Lander,Erez Lieberman Aiden,Erez Lieberman Aiden,Erez Lieberman Aiden +24 more
TL;DR: It is shown that it is possible to disrupt, restore, and move loops and domains using targeted mutations as small as a single base pair at CTCF sites, and it is found that the observed contact domains are inconsistent with the equilibrium state for an ordinary condensed polymer.
Journal Article
Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes
Adrian L. Sanborn,Suhas S.P. Rao,Su-Chen Huang,Neva C. Durand,Miriam H. Huntley,Andrew I. Jewett,Ivan D. Bochkov,Dharmaraj Chinnappan,Ashok Cutkosky,Jian Li,Kristopher Geeting,Doug McKenna,Elena K. Stamenova,Andreas Gnirke,Alexandre Melnikov,Eric S. Lander,Erez Lieberman Aiden +16 more
TL;DR: In this article, high-resolution spatial proximity maps are consistent with a model in which a complex, including the proteins CCCTC-binding factor (CTCF) and cohesin, mediates the formation of loops by a process of extrusion.
Journal ArticleDOI
Drug-Resistant E. coli Bacteremia Transmitted by Fecal Microbiota Transplant.
Zachariah DeFilipp,Patricia P. Bloom,Mariam Torres Soto,Michael K. Mansour,Mohamad R. Abdul Sater,Miriam H. Huntley,Sarah E Turbett,Raymond T. Chung,Yi-Bin Chen,Elizabeth L. Hohmann +9 more
TL;DR: Two patients in whom extended-spectrum beta-lactamase-producing Escherichia coli bacteremia occurred after they had undergone FMT are described; both cases were linked to the same stool donor by means of genomic sequencing.