D
Di Wu
Researcher at Chinese Academy of Sciences
Publications - 8
Citations - 327
Di Wu is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: RNA silencing & RNA. The author has an hindex of 5, co-authored 8 publications receiving 179 citations. Previous affiliations of Di Wu include Wuhan University.
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Journal ArticleDOI
Plasma metabolomic and lipidomic alterations associated with COVID-19
Di Wu,Ting Shu,Xiaobo Yang,Jian-Xin Song,Mingliang Zhang,Chengye Yao,Wen Liu,Muhan Huang,Yuan Yu,Qingyu Yang,Tingju Zhu,Jiqian Xu,Jingfang Mu,Yaxin Wang,Hong Wang,Tang Tang,Yujie Ren,Yongran Wu,Shuhai Lin,Yang Qiu,Dingyu Zhang,You Shang,Xi Zhou +22 more
TL;DR: Target metabolomic and lipidomic analyses of plasma from a cohort of patients with COVID-19 found that metabolite and lipid alterations exhibit apparent correlation with the course of disease in these patients, indicating that the development of CO VID-19 affected their whole-body metabolism.
Journal ArticleDOI
Drosophila Dicer-2 has an RNA interference-independent function that modulates Toll immune signaling.
Zhaowei Wang,Di Wu,Yongxiang Liu,Xiaoling Xia,Wanyun Gong,Yang Qiu,Jie Yang,Ya Zheng,Jing-Jing Li,Yu-Feng Wang,Ye Xiang,Yuanyang Hu,Xi Zhou +12 more
TL;DR: These findings uncover a novel RNAi-independent function of Dicer-2 in the posttranscriptional regulation of Toll protein expression and signaling, indicate an unexpected intersection of the RNAi pathway and the Toll pathway, and provide new insights into Toll immune signaling, Drosophila Diter-2, and probably Dicer andDicer-related proteins in other organisms.
Posted ContentDOI
Plasma Metabolomic and Lipidomic Alterations Associated with COVID-19
Di Wu,Ting Shu,Xiaobo Yang,Jian-Xin Song,Mingliang Zhang,Chengye Yao,Wen Liu,Muhan Huang,Yuan Yu,Qingyu Yang,Tingju Zhu,Jiqian Xu,Jingfang Mu,Yaxin Wang,Hong Wang,Tang Tang,Yujie Ren,Yongran Wu,Shuhai Lin,Yang Qiu,Dingyu Zhang,You Shang,Xi Zhou +22 more
TL;DR: Untargeted metabolomic and lipidomic analyses of plasma from a cohort of COVID-19 patients who had experienced different symptoms found the metabolite and lipid alterations exhibit apparent correlation with the course of disease in these patients, indicating that the development of CO VID-19 affected patient metabolism.
Journal ArticleDOI
Characterization of a Nodavirus Replicase Revealed a de Novo Initiation Mechanism of RNA Synthesis and Terminal Nucleotidyltransferase Activity
TL;DR: This study revealed the initiation mechanism and terminal repair function of the replicase in Nodaviridae and uncovered that WhNV protein A contains a terminal nucleotidyltransferase (TNTase) activity, which is the first time such an activity has been identified in nodaviruses.
Journal ArticleDOI
A picorna-like virus suppresses the N-end rule pathway to inhibit apoptosis.
Zhaowei Wang,Zhaowei Wang,Xiaoling Xia,Xiaoling Xia,Xiaoling Xia,Xueli Yang,Xueyi Zhang,Xueyi Zhang,Yongxiang Liu,Yongxiang Liu,Di Wu,Di Wu,Yuan Fang,Yuan Fang,Yujie Liu,Yujie Liu,Jiuyue Xu,Yang Qiu,Xi Zhou,Xi Zhou +19 more
TL;DR: It is found that viral infection promoted the accumulation of caspase-cleaved Drosophila inhibitor of apoptosis 1 by inducing the degradation of N-terminal amidohydrolase 1 (NTAN1), a key N-end rule component that identifies N-degron to initiate the process.