Plasma metabolomic and lipidomic alterations associated with COVID-19
Di Wu,Ting Shu,Xiaobo Yang,Jian-Xin Song,Mingliang Zhang,Chengye Yao,Wen Liu,Muhan Huang,Yuan Yu,Qingyu Yang,Tingju Zhu,Jiqian Xu,Jingfang Mu,Yaxin Wang,Hong Wang,Tang Tang,Yujie Ren,Yongran Wu,Shuhai Lin,Yang Qiu,Dingyu Zhang,You Shang,Xi Zhou +22 more
TLDR
Target metabolomic and lipidomic analyses of plasma from a cohort of patients with COVID-19 found that metabolite and lipid alterations exhibit apparent correlation with the course of disease in these patients, indicating that the development of CO VID-19 affected their whole-body metabolism.Abstract:
The pandemic of the coronavirus disease 2019 (COVID-19) has become a global public health crisis. The symptoms of COVID-19 range from mild to severe, but the physiological changes associated with COVID-19 are barely understood. In this study, we performed targeted metabolomic and lipidomic analyses of plasma from a cohort of patients with COVID-19 who had experienced different symptoms. We found that metabolite and lipid alterations exhibit apparent correlation with the course of disease in these patients, indicating that the development of COVID-19 affected their whole-body metabolism. In particular, malic acid of the TCA cycle and carbamoyl phosphate of the urea cycle result in altered energy metabolism and hepatic dysfunction, respectively. It should be noted that carbamoyl phosphate is profoundly down-regulated in patients who died compared with patients with mild symptoms. And, more importantly, guanosine monophosphate (GMP), which is mediated not only by GMP synthase but also by CD39 and CD73, is significantly changed between healthy subjects and patients with COVID-19, as well as between the mild and fatal cases. In addition, dyslipidemia was observed in patients with COVID-19. Overall, the disturbed metabolic patterns have been found to align with the progress and severity of COVID-19. This work provides valuable knowledge about plasma biomarkers associated with COVID-19 and potential therapeutic targets, as well as an important resource for further studies of the pathogenesis of COVID-19.read more
Citations
More filters
Journal ArticleDOI
Plasma Proteomics Identify Biomarkers and Pathogenesis of COVID-19.
Ting Shu,Wanshan Ning,Di Wu,Jiqian Xu,Qiangqiang Han,Muhan Huang,Xiaojing Zou,Qingyu Yang,Yang Yuan,Yuanyuan Bie,Shangwen Pan,Jingfang Mu,Yang Han,Xiaobo Yang,Hong Zhou,Ruiting Li,Yujie Ren,Xi Chen,Shanglong Yao,Yang Qiu,Ding Yu Zhang,Yu Xue,You Shang,Xi Zhou +23 more
TL;DR: A machine learning-based pipeline was developed to identify 11 proteins as biomarkers and a set of biomarker combinations, which were validated by an independent cohort and accurately distinguished and predicted COVID-19 outcomes.
Journal ArticleDOI
Large-Scale Plasma Analysis Revealed New Mechanisms and Molecules Associated with the Host Response to SARS-CoV-2.
Elettra Barberis,Sara Timo,Elia Amede,Virginia Vita Vanella,Chiara Puricelli,Giuseppe Cappellano,Davide Raineri,Micol Giulia Cittone,Eleonora Rizzi,Anita R. Pedrinelli,Veronica Vassia,Francesco G. Casciaro,Simona Priora,Ilaria Nerici,Alessandra Galbiati,Eyal Hayden,Marco Falasca,Rosanna Vaschetto,Pier Paolo Sainaghi,U. Dianzani,Roberta Rolla,Annalisa Chiocchetti,Gianluca Baldanzi,Emilio Marengo,Marcello Manfredi +24 more
TL;DR: This study provided further evidence for considering phospholipase A2 (PLA2) activity as a potential key factor in the pathogenesis of COVID-19 and a possible therapeutic target, and found that several circulating lipids acted as potential biomarkers, and triglycerides and free fatty acids were well correlated to the severity of the disease.
Journal ArticleDOI
SARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profiles of Serum.
Chiara Bruzzone,Maider Bizkarguenaga,Rubén Gil-Redondo,Tammo Diercks,Eunate Arana,Aitor García de Vicuña,Marisa Seco,Alexandre Bosch,Asis Palazon,Itxaso San Juan,Ana Laín,Jon Gil-Martínez,Ganeko Bernardo-Seisdedos,David Fernández-Ramos,Fernando Lopitz-Otsoa,Nieves Embade,Shelly C. Lu,José M. Mato,Oscar Millet +18 more
TL;DR: The results are consistent with a model in which SARS-CoV-2 infection induces liver damage associated with dyslipidemia and oxidative stress, and PCA analyses discriminating both cohorts highlighted the impact that the infection has in overall metabolism.
Journal ArticleDOI
Integrative Modeling of Quantitative Plasma Lipoprotein, Metabolic, and Amino Acid Data Reveals a Multiorgan Pathological Signature of SARS-CoV-2 Infection.
Torben Kimhofer,Samantha Lodge,Luke Whiley,Luke Whiley,Nicola Gray,Ruey Leng Loo,Nathan G. Lawler,Philipp Nitschke,Sze-How Bong,David Morrison,Sofina Begum,Toby Richards,Bu B. Yeap,Chris Smith,Kenneth G. C. Smith,Elaine Holmes,Elaine Holmes,Jeremy K. Nicholson,Jeremy K. Nicholson,Jeremy K. Nicholson +19 more
TL;DR: The breadth of the disturbed pathways indicates a systemic signature of SARS-CoV-2 positivity that includes elements of liver dysfunction, dyslipidemia, diabetes, and coronary heart disease risk that is consistent with recent reports that COVID-19 is a systemic disease affecting multiple organs and systems.
Journal ArticleDOI
Cutting Edge: Severe SARS-CoV-2 Infection in Humans Is Defined by a Shift in the Serum Lipidome, Resulting in Dysregulation of Eicosanoid Immune Mediators.
Benjamin Schwarz,Lokesh Sharma,Lydia M. Roberts,Xiaohua Peng,Santos Bermejo,Ian Leighton,Arnau Casanovas-Massana,Maksym Minasyan,Shelli F. Farhadian,Albert I. Ko,Yale Impact Team,Charles S. Dela Cruz,Catharine M. Bosio +12 more
TL;DR: Examining LMs and polyunsaturated fatty acid precursor lipids in serum from hospitalized COVID-19 patients shows that moderate and severe disease are separated by specific differences in abundance of immune-regulatory and proinflammatory LMs, providing mechanistic insight into an immuno-lipidomic imbalance in severe CO VID-19.
References
More filters
Journal ArticleDOI
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
Journal ArticleDOI
Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
Dawei Wang,Bo Hu,Chang Hu,Fangfang Zhu,Xing Liu,Jing Zhang,Binbin Wang,Hui Xiang,Zhenshun Cheng,Yong Xiong,Yan Zhao,Yirong Li,Xinghuan Wang,Zhiyong Peng +13 more
TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
Journal ArticleDOI
Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
Journal ArticleDOI
Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study.
Xiaobo Yang,Yuan Yu,Jiqian Xu,Huaqing Shu,Jia'an Xia,Hong Liu,Hong Liu,Yongran Wu,Lu Zhang,Zhui Yu,Minghao Fang,Ting Yu,Yaxin Wang,Shangwen Pan,Xiaojing Zou,Shiying Yuan,You Shang,You Shang +17 more
TL;DR: The clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia who were admitted to the intensive care unit (ICU) of Wuhan Jin Yin-tan hospital between late December, 2019 and Jan 26, 2020 are described.
Journal ArticleDOI
The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China
TL;DR: The COVID-19 epidemic has spread very quickly and only took 30 days to expand from Hubei to the rest of Mainland China, with many people returning from a long holiday, China needs to prepare for the possible rebound of the epidemic.
Related Papers (5)
Proteomic and Metabolomic Characterization of COVID-19 Patient Sera.
Bo Shen,Xiao Yi,Yaoting Sun,Xiaojie Bi,Juping Du,Chao Zhang,Sheng Quan,Fangfei Zhang,Rui Sun,Liujia Qian,Weigang Ge,Wei Liu,Shuang Liang,Hao Chen,Ying Zhang,Jun Li,Jiaqin Xu,Zebao He,Baofu Chen,Jing Wang,Haixi Yan,Yufen Zheng,Donglian Wang,Jiansheng Zhu,Ziqing Kong,Zhouyang Kang,Xiao Liang,Xuan Ding,Guan Ruan,Nan Xiang,Xue Cai,Huanhuan Gao,Lu Li,Sainan Li,Qi Xiao,Tian Lu,Yi Zhu,Huafen Liu,Haixiao Chen,Tiannan Guo +39 more
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
A pneumonia outbreak associated with a new coronavirus of probable bat origin
Peng Zhou,Xing-Lou Yang,Xian Guang Wang,Ben Hu,Lei Zhang,Wei Zhang,Hao Rui Si,Yan Zhu,Bei Li,Chao Lin Huang,Hui-Dong Chen,Jing Chen,Yun Luo,Hua Guo,Ren Di Jiang,Meiqin Liu,Ying Chen,Xu Rui Shen,Xi Wang,Xiao Shuang Zheng,Kai Zhao,Quanjiao Chen,Fei Deng,Lin Lin Liu,Bing Yan,Fa Xian Zhan,Yan-Yi Wang,Gengfu Xiao,Zhengli Shi +28 more
Clinical Characteristics of Coronavirus Disease 2019 in China.
Wei-jie Guan,Zhengyi Ni,Yu Hu,Wenhua Liang,Chun-Quan Ou,Jianxing He,Lei Liu,Hong Shan,Chunliang Lei,David S.C. Hui,Bin Du,Lanjuan Li,Guang Zeng,Kowk-Yung Yuen,Ruchong Chen,Chun-Li Tang,Tao Wang,Ping-Yan Chen,Jie Xiang,Shiyue Li,Jinlin Wang,Zi-jing Liang,Yi-xiang Peng,Li Wei,Yong Liu,Ya-hua Hu,Peng Peng,Jian-ming Wang,Ji-yang Liu,Zhong Chen,Gang Li,Zhi-jian Zheng,Shao-qin Qiu,Jie Luo,Chang-jiang Ye,Shao-yong Zhu,Nanshan Zhong +36 more