D
Diana Mandelker
Researcher at Johns Hopkins University
Publications - 17
Citations - 4192
Diana Mandelker is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 8, co-authored 10 publications receiving 4095 citations. Previous affiliations of Diana Mandelker include Johns Hopkins University School of Medicine & Howard Hughes Medical Institute.
Papers
More filters
PatentDOI
Consensus coding sequences of human breast and colorectal cancers
Tobias Sjöblom,Sian Jones,D. Williams Parsons,Laura D. Wood,Jimmy Lin,Thomas D. Barber,Diana Mandelker,Bert Vogelstein,Kenneth W. Kinzler,Victor E. Velculesu +9 more
TL;DR: In this paper, the authors analyzed 13,023 genes in 11 breast and 11 colorectal cancers and found that individual tumors accumulate an average of 90 mutant genes but only a subset of these contribute to the neoplastic process.
Journal ArticleDOI
The Structure of a Human p110α/p85α Complex Elucidates the Effects of Oncogenic PI3Kα Mutations
Chuan Hsiang Huang,Chuan Hsiang Huang,Diana Mandelker,Diana Mandelker,Oleg Schmidt-Kittler,Oleg Schmidt-Kittler,Yardena Samuels,Yardena Samuels,Victor E. Velculescu,Victor E. Velculescu,Kenneth W. Kinzler,Kenneth W. Kinzler,Bert Vogelstein,Bert Vogelstein,Sandra B. Gabelli,Sandra B. Gabelli,L. Mario Amzel,L. Mario Amzel +17 more
TL;DR: The structure of PI3Kα shows that many of the mutations occur at residues lying at the interfaces between p110 α and p85α or between the kinase domain of p110α and other domains within the catalytic subunit, which suggests specific mechanisms for the effect of oncogenic mutations.
Journal ArticleDOI
A frequent kinase domain mutation that changes the interaction between PI3Kα and the membrane
Diana Mandelker,Sandra B. Gabelli,Oleg Schmidt-Kittler,Jiuxiang Zhu,Ian Cheong,Chuan Hsiang Huang,Kenneth W. Kinzler,Bert Vogelstein,L.M. Amzel +8 more
TL;DR: Structural and biochemical data suggest a previously undescribed mechanism for mutational activation of a kinase that involves perturbation of its interaction with the cellular membrane, which is differentially regulated by lipid membrane composition.
Journal ArticleDOI
PGP9.5 promoter methylation is an independent prognostic factor for esophageal squamous cell carcinoma.
Diana Mandelker,Keishi Yamashita,Yutaka Tokumaru,Koshi Mimori,David L. Howard,Yoichi Tanaka,André Lopes Carvalho,Wei Wen Jiang,Hannah Lui Park,Myoung Sook Kim,Motonobu Osada,Masaki Mori,David Sidransky +12 more
TL;DR: Results suggest that PGP9.5 promoter methylation could be a clinically applicable marker for ESCC progression, as well as an independent prognostic factor for ES CC survival.
Journal ArticleDOI
Structural comparisons of class I phosphoinositide 3-kinases
L. Mario Amzel,Chuan Hsiang Huang,Diana Mandelker,Christoph Lengauer,Christoph Lengauer,Sandra B. Gabelli,Bert Vogelstein +6 more
TL;DR: The recently determined structure of PI3Kα reveals features that distinguish this enzyme from related lipid kinases, and identified structural features that could potentially be exploited for the design of isoform-specific inhibitors.