S
Sian Jones
Researcher at Johns Hopkins University
Publications - 21
Citations - 6721
Sian Jones is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 11, co-authored 21 publications receiving 6619 citations. Previous affiliations of Sian Jones include Howard Hughes Medical Institute.
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PatentDOI
Consensus coding sequences of human breast and colorectal cancers
Tobias Sjöblom,Sian Jones,D. Williams Parsons,Laura D. Wood,Jimmy Lin,Thomas D. Barber,Diana Mandelker,Bert Vogelstein,Kenneth W. Kinzler,Victor E. Velculesu +9 more
TL;DR: In this paper, the authors analyzed 13,023 genes in 11 breast and 11 colorectal cancers and found that individual tumors accumulate an average of 90 mutant genes but only a subset of these contribute to the neoplastic process.
PatentDOI
Genomic landscapes of human breast and colorectal cancers
Laura D. Wood,Williams D. Parsons,Sian Jones,Jimmy Lin,Tobias Sjöblom,Thomas D. Barber,Giovanni Parmigiani,Victor E. Velculescu,Kenneth W. Kinzler,Bert Vogelstein +9 more
TL;DR: Based on analysis of exons representing 20,857 transcripts from 18,191 genes, the authors concluded that the genomic landscapes of breast and colorectal cancers are composed of a handful of commonly mutated gene "mountains" and a much larger number of gene "hills" that are mutated at low frequency.
Journal ArticleDOI
Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors
Ming Zhang,Yuxuan Wang,Sian Jones,Mark Sausen,Kevin McMahon,Rajni Sharma,Qing Wang,Allan J. Belzberg,Kaisorn L. Chaichana,Gary L. Gallia,Ziya L. Gokaslan,Greg J. Riggins,Jean Paul Wolinksy,Laura D. Wood,Elizabeth A. Montgomery,Ralph H. Hruban,Kenneth W. Kinzler,Nickolas Papadopoulos,Bert Vogelstein,Chetan Bettegowda +19 more
TL;DR: Sixteen MPNSTs but none of the neurofibromas tested were found to have somatic mutations in SUZ12, implicating it as having a central role in malignant transformation.
Journal ArticleDOI
Targeted sequencing reveals clonal genetic changes in the progression of early lung neoplasms and paired circulating DNA
Evgeny Izumchenko,Xiaofei Chang,Mariana Brait,Elana J. Fertig,Luciane T. Kagohara,Atul Bedi,Luigi Marchionni,Nishant Agrawal,Rajani Ravi,Sian Jones,Mohammad O. Hoque,William H. Westra,David Sidransky +12 more
TL;DR: Insight is provided into the heterogeneity of clonal events in the progression of early lung neoplasia and it is demonstrated that these events can be detected even before neoplasms have invaded and acquired malignant potential.
Journal ArticleDOI
Somatic mutations of PPP2R1A in ovarian and uterine carcinomas.
Ie Ming Shih,Pradeep K. Panuganti,Kuan Tin Kuo,Tsui Lien Mao,Elisabetta Kuhn,Sian Jones,Victor E. Velculescu,Robert J. Kurman,Tian Li Wang +8 more
TL;DR: Data provide new evidence that PPP2R1A somatic mutations occur in certain types of uterine and ovarian neoplastic lesions, especially uterine serous carcinomas, and suggest that mutation of PPP1A may participate in the pathogenesis of ovarian type I and uterine type II carcinomas.