Diane Gingras

TL;DR: Morphological and functional analyses indicated that distinct forms of autophagy facilitated the presentation of HSV-1 antigens on MHC class I molecules, which suggests a complex interaction between the vacuolar and MHCclass I presentation pathways.

TL;DR: Evidence is provided for the expression of P-gp in human and rodent brain capillary along their plasma membranes as well as at sites of protein synthesis, glycosylation, and membrane trafficking, and suggests that this glycoprotein may regulate drug transport processes in the entire CNS BBB at both the cellular and subcellular level.

TL;DR: It is found that injection of apoptotic exosome-like vesicles apoExo stimulated autoantibody production in mice, which led to increased graft rejection after transplant, and proteasome inhibitors could provide a new therapeutic avenue for graft rejection.

TL;DR: The results demonstrate the cellular/subcellular location and functional expression of P‐glycoprotein in rat astrocytes and suggest that this glial compartment may play an important role in the regulation of drug transport in the CNS.

TL;DR: Blood analysis made at several time points has demonstrated a rapid increase in circulating levels of insulin followed by significant and consistent decreases in blood glucose, which indicates that biologically active insulin is absorbed by the intestinal mucosa and transferred to the circulation.