Eric Boilard

TL;DR: The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities, and a checklist is provided with summaries of key points.

TL;DR: A previously unappreciated role for platelets and their activation-induced microparticles in inflammatory joint diseases is demonstrated and the collagen receptor glycoprotein VI is identified as a key trigger for platelet microparticle generation in arthritis pathophysiology.

TL;DR: It is shown that activated platelets release respiratory-competent mitochondria, both within membrane-encapsulated microparticles and as free organelles, at the midpoint of a potent mechanism leading to inflammatory responses.

TL;DR: It is demonstrated that human platelets activated with thrombin preferentially release their miR-223 content in MPs, which support a scenario by which platelet MPs may act as intercellular carriers of functional Ago2•microRNA complexes that may exert heterotypic regulation of gene expression in endothelial cells, and possibly other recipient cells of the circulatory system.

TL;DR: It is demonstrated that platelets release their alpha- and dense-granule contents in both nonsevere and severe forms of COVID-19, as they release various sets of molecules through the different stages of the disease.