D
Diane M. Simeone
Researcher at University of Michigan
Publications - 297
Citations - 23025
Diane M. Simeone is an academic researcher from University of Michigan. The author has contributed to research in topics: Pancreatic cancer & Cancer. The author has an hindex of 66, co-authored 261 publications receiving 20569 citations. Previous affiliations of Diane M. Simeone include New York University & University of Texas MD Anderson Cancer Center.
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Nerve growth factor promotes neurite outgrowth in guinea pig myenteric plexus ganglia
TL;DR: Primary cultures of neonatal guinea pig myenteric plexus ganglia were used to examine the ability of NGF to stimulate morphological development in enteric neurons, and NGF demonstrates activities in cultured enteric ganglia that stimulate Morphological development.
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Automated integration of monolith-based protein separation with on-plate digestion for mass spectrometric analysis of esophageal adenocarcinoma human epithelial samples.
Chul Yoo,Jia Zhao,Manoj Pal,Katherine E Hersberger,Christian G. Huber,Diane M. Simeone,David G. Beer,David M. Lubman +7 more
TL;DR: A unique approach of automating the integration of monolithic capillary HPLC‐based protein separation and on‐plate digestion for subsequent MALDI‐MS analysis has been developed, obtaining rapid protein identifications through PMF and sequencing analyses with high sequence coverage.
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Acetylcholine-induced calcium signaling associated with muscarinic receptor activation in cultured myenteric neurons.
TL;DR: The findings suggest that ACh induces increases in [Ca2+]i in myenteric neurons by promoting influx of extracellular Ca2+ through L-type voltage-dependent Ca1+ channels by activation of the M1 muscarinic receptor subtype.
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Adenoviral-mediated gene transfer of a constitutively active retinoblastoma gene inhibits human pancreatic tumor cell proliferation
TL;DR: Adenoviral-mediated gene delivery of a constitutively active, nonphosphorylatable form of the retinoblastoma gene (AdRb) produces significant growth inhibition in human pancreatic cancer cells and is not a result of apoptosis.
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Recent advances in pancreatic surgery
Filip Bednar,Diane M. Simeone +1 more
TL;DR: Pancreatic surgery is a rapidly evolving field with the promise to significantly improve outcomes for patients with a variety of pancreatic diseases in the future, and Laparoscopic and robotic approaches married with new emerging technologies have the potential to transform the practice of pancreatIC surgery.