D
Diane M. Simeone
Researcher at University of Michigan
Publications - 297
Citations - 23025
Diane M. Simeone is an academic researcher from University of Michigan. The author has contributed to research in topics: Pancreatic cancer & Cancer. The author has an hindex of 66, co-authored 261 publications receiving 20569 citations. Previous affiliations of Diane M. Simeone include New York University & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
Inhibition Of The Notch Signaling Pathway Targets Cancer Stem Cells In Pancreatic Ductal Adenocarcinoma
Posted ContentDOI
Multiplex Enrichment and Detection of Rare KRAS Mutations in Liquid Biopsy Samples using Digital Droplet Pre-Amplification
Erica D. Pratt,David Bing Zhen,Robert W. Cowan,Sara L. Manning,Edmund Qiao,Heather Cameron,Kara Schradle,Diane M. Simeone,Andrew D. Rhim +8 more
TL;DR: The Multiplex Enrichment using Droplet Pre-Amplification (MED-Amp) method, which combines single-molecule emulsification and short-round PCR preamplification with digital droplet PCR (ddPCR) detection of mutant DNA template, is presented.
Proceedings ArticleDOI
Abstract B15: Therapeutic potential of targeting amino acid metabolism in pancreatic cancer
Martin E. Fernandez-Zapico,Dae Won Kim,Philip A. Philip,Alexander G Vandell,Jonathan Eckard,Ron Korn,Giuseppe Del Priore,Diane M. Simeone +7 more
TL;DR: Altered amino acid (LAT1) metabolism has been shown to be a negative prognosticator in pancreatic cancer outcomes and progression and initial clinical and preclinical results with SM-88 indicate that this agent could pose a novel approach in the treatment of Pancreatic cancer.
Journal ArticleDOI
Pilot Study of Personalized Video Visit Summaries for Patients With Cancer.
TL;DR: It is hypothesized that an oncologist can feasibly record and deliver a custom video summary of the consultation that covers the diagnosis, recommended testing, treatment plan, and follow-up in < 5 minutes.
Journal ArticleDOI
Abstract PR012: Perioperative liver biopsy captures features of the liver pre-metastatic niche and predicts metastatic outcome after pancreatic cancer resection
Linda Bojmar,Constantinos P. Zambirinis,Jonathan M. Hernandez,Jayasree Chakraborty,Samer Hanna,Diane M. Simeone,David P. Kelsen,Haiying Zhang,Irina Matei,Per Sandström,Robert E. Schwartz,William R. Jarnagin,David Lyden +12 more
TL;DR: Bojmar et al. as mentioned in this paper evaluated liver biopsies from 49 patients with localized pancreatic cancer to characterize the cellular, molecular and metabolic features that define the pre-metastatic niche and that may, in turn, be used as biomarkers to stratify the metastatic risk, and as therapeutic targets.