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Diane M. Simeone
Researcher at University of Michigan
Publications - 297
Citations - 23025
Diane M. Simeone is an academic researcher from University of Michigan. The author has contributed to research in topics: Pancreatic cancer & Cancer. The author has an hindex of 66, co-authored 261 publications receiving 20569 citations. Previous affiliations of Diane M. Simeone include New York University & University of Texas MD Anderson Cancer Center.
Papers
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Proceedings ArticleDOI
Modeling Reflectance and Fluorescence Spectra of Human Pancreatic Tissues for Cancer Diagnostics
Robert H. Wilson,Malavika Chandra,James M. Scheiman,David G. Heidt,Diane M. Simeone,Barbara J. McKenna,Mary Ann Mycek +6 more
TL;DR: Reflectance and fluorescence spectroscopy were used in a limited pilot study to probe freshly excised human pancreatic tissues; mathematical modeling of the data quantitatively showed biologically relevant physical differences between normal tissue, pancreatitis, and cancer.
Screening for depression, sleep-related disturbances, and anxiety in patients with adenocarcinoma of
Andrew D. Boyd,Richard A. Brown,Carl E. Henrickson,Jean Hampton,Binhai Zhu,Farideh Almani,Edgar Ben-Josef,Mark M. Zalupski,Diane M. Simeone,James R. Taylor,Rachel Armitage,Michelle Riba +11 more
TL;DR: Depression, anxiety, and sleep problems are evident in patients with pancreatic cancer and Prospective, longitudinal studies are needed to determine if these comorbid symptoms impact outcome and clinical course.
Journal ArticleDOI
POLQ inhibition elicits an immune response in homologous recombination–deficient pancreatic adenocarcinoma via cGAS/STING signaling
Grace Oh,Annie Wang,Ling Wang,Jiufeng Li,Gregor Werba,Daniel Weissinger,Ende Zhao,Surajit Dhara,Rosmel Hernandez,Amanda Ackermann,Sarina Y. Porcella,Despoina Kalfakakou,Igor Dolgalev,Emily Kawaler,Talia Golan,Theodore H. Welling,Agnel Sfeir,Diane M. Simeone +17 more
TL;DR: In this article , the authors showed that the inhibition of polymerase theta (Polθ) is synthetically lethal in combination with mutations in homologous recombination-repair (HR-repair) proteins in pancreatic ductal adenocarcinoma (PDAC).
Journal ArticleDOI
Phase I study of definitive chemoradiation with gemcitabine and the WEE1 inhibitor AZD1775 in unresectable pancreatic cancer.
Kyle C. Cuneo,Meredith A. Morgan,Matthew J. Schipper,Jonathan Maybaum,Mahmoud M. Al-Hawary,Diane M. Simeone,Vaibhav Sahai,Mark M. Zalupski,Theodore S. Lawrence +8 more
TL;DR: A phase I dose escalation study of the WEE1 inhibitor AZD1775 with gemcitabine and radiation in patients with unresectable pancreatic cancer to determine the maximum tolerated dose.
Patent
Pancreatic cancer markers
TL;DR: In this article, a method and compositions for the identification of protein glycosylation patterns associated with pancreatic cancer was presented, and the method was applied to pancreatic markers.