Diego Dal Ben

TL;DR: The central role played by the P2X7 receptor in promoting inflammation and driving innate and adaptive immunity is discussed, with an in‐depth knowledge of its structure and of the associated signal transduction mechanisms needed for an effective therapeutic development.

TL;DR: After many years from the introduction in therapy of ChE-Is, the combination with other classes of drugs may represent the chance for a renewed interest of Ch E-Is in the treatment of adult-onset dementia disorders.

TL;DR: An overview of the present knowledge about CK2 inhibitors is presented, with special reference to the information drawn from two recently solved crystal structures of CK2alpha in complex with emodin and with 4,5,6,7-tetrabromo-2-azabenzimidazole (TBB), this latter being the most specific CK2 inhibitor known to date.

TL;DR: Structural features of P2X7, chemical properties of its agonist, antagonist, and allosteric modulators are described and an overview on recent literature suggesting that P2x7 single-nucleotide polymorphisms could be exploited as diagnostic biomarkers for the development of tailored therapies is given.

TL;DR: Results show that the presence of the bromine atom in 8-position of 9-substituted adenines promotes in general the interaction with the adenosine receptors, in particular at the A(2A) subtype.