Diego Navarro

TL;DR: DKK-1 gene induction constitutes a novel mechanism of inhibition of Wnt signalling and antitumour action by 1,25(OH)2D3, and this effect is dose dependent, slow and depends on the presence of a transcription-competent nuclear vitamin D receptor (VDR).

TL;DR: A 2D in vitro system for long-term enrichment of pancreatic CSCs defined by increased CSC biomarker and pluripotency gene expression, greater tumorigenic potential, induced but reversible quiescence, increased OXPHOS activity, enhanced invasiveness, and upregulated immune evasion properties is described.

TL;DR: It is shown that ISGylation is necessary for pancreatic cancer stem cell self-renewal and tumourigenesis by supporting the recycling of non-functional mitochondria and the ubiquitin-like modifier ISG15 exerts post-translational protein regulation through ISgylation.

TL;DR: The results show that EWS/FLI1 inhibits both DKK-1 expression as well as beta-catenin/TCF-dependent transcription, which could contribute to progression of tumours of the Ewing family.

TL;DR: The results show that HRSV triggers a DNA damage-mediated cellular senescence program probably mediated by oxidative stress, and suggest that this program might contribute to the physiopathology of the infection, tissue remodeling and aging, and might be associated to long-term consequences of H RSV infections.