Diego Rey

TL;DR: The understanding of gene regulation and the role of polymorphic sites on gene function may permit an individualized approach for the future use of HLA-G for therapeutic purposes.

TL;DR: The present review gathers most available HLA data already obtained about First Native American populations, which raise some doubts about the classical three waves of American peopling hypothesis and shows that gene genealogy analises should be completed with allele frequency analyses in population relatednes and migrations studies.

TL;DR: In this article, the relatedness of First America Inhabitants with Pacific Islanders by using autosomal genetic markers: the HLA alleles is investigated. But, there is no either genetic, cultural or anthropological homogeneity within these groups, while different First America inhabitants' ethnic groups, Amerindians, Na-Dene speakers, Aleuts and Eskimo there exist.

TL;DR: The results suggest that the Mexican Mestizo population be principally characterized by haplotypes presents in Amerindian and Caucasian populations with a low frequency of Black haplotypes.

TL;DR: One of the nine most frequent extended haplotypes seems to be from European origin, suggesting the existence of a degree of admixture with Europeans in the Mapuche sample, and the medical importance of calculating HLA profile is discussed.