E
Erick C. Castelli
Researcher at Sao Paulo State University
Publications - 117
Citations - 3001
Erick C. Castelli is an academic researcher from Sao Paulo State University. The author has contributed to research in topics: Human leukocyte antigen & Haplotype. The author has an hindex of 26, co-authored 105 publications receiving 2419 citations. Previous affiliations of Erick C. Castelli include University of São Paulo & Universidade Federal de Goiás.
Papers
More filters
Journal ArticleDOI
Implications of the polymorphism of HLA-G on its function, regulation, evolution and disease association
Eduardo Antônio Donadi,Erick C. Castelli,Antonio Arnaiz-Villena,Michel Roger,Diego Rey,Philippe Moreau +5 more
TL;DR: The understanding of gene regulation and the role of polymorphic sites on gene function may permit an individualized approach for the future use of HLA-G for therapeutic purposes.
Journal ArticleDOI
The genetic structure of 3′untranslated region of the HLA-G gene: polymorphisms and haplotypes
Erick C. Castelli,Celso T. Mendes-Junior,N. H. S. Deghaide,R. S. de Albuquerque,Yara Costa Netto Muniz,Renata Simões,Edgardo D. Carosella,Philippe Moreau,Eduardo Antônio Donadi +8 more
TL;DR: A high linkage disequilibrium among the variation sites was detected, especially among the 14-bp insertion and the alleles +3142G and +3187A, all previously associated with low mRNA availability, demonstrating that their effects are not independent.
Journal ArticleDOI
Polymorphic Sites at the 3’ Untranslated Region of the HLA-G Gene Are Associated with Differential hla-g Soluble Levels in the Brazilian and French Population
Gustavo Martelli-Palomino,Gustavo Martelli-Palomino,Gustavo Martelli-Palomino,João Alexandre Trés Pancotto,João Alexandre Trés Pancotto,João Alexandre Trés Pancotto,Yara Costa Netto Muniz,Yara Costa Netto Muniz,Celso T. Mendes-Junior,Erick C. Castelli,Juliana Doblas Massaro,Irene Krawice-Radanne,Irene Krawice-Radanne,Isabelle Poras,Isabelle Poras,Vera Rebmann,Edgardo D. Carosella,Edgardo D. Carosella,Nathalie Rouas-Freiss,Nathalie Rouas-Freiss,Philippe Moreau,Philippe Moreau,Eduardo Antônio Donadi +22 more
TL;DR: The analyses of 3’UTR haplotypes showed that UTR-1 (DelTGCCCGC) was associated with higher expression of sHLA-G, whereas U TRs (UTR-2/3/4/6) exhibited intermediate levels, and the identification of individuals genetically programmed to differentially express HLA-G may help on defining novel strategies to control the immune response against the underlying disorder.
Journal ArticleDOI
In silico analysis of microRNAS targeting the HLA-G 3' untranslated region alleles and haplotypes.
Erick C. Castelli,Philippe Moreau,Alynne Oya e Chiromatzo,Celso T. Mendes-Junior,Luciana C. Veiga-Castelli,Layale Yaghi,Silvana Giuliatti,Edgardo D. Carosella,Eduardo Antônio Donadi +8 more
TL;DR: Results suggest that these miRNAs might play a relevant role on the HLA-G expression pattern, and the lowest free energies that could potentially lead to an mRNA degradation or translational repression are ranked.
Journal ArticleDOI
A Comprehensive Study of Polymorphic Sites along the HLA-G Gene: Implication for Gene Regulation and Evolution
Erick C. Castelli,Celso T. Mendes-Junior,Luciana C. Veiga-Castelli,Michel Roger,Philippe Moreau,Eduardo Antônio Donadi +5 more
TL;DR: Several lines of evidence indicate that HLA-G polymorphisms at the 5'-upstream regulatory region (5' URR) and 3'-untranslated region (3' UTR) may influence the Hla-G expression levels, and several lines ofevidence for balancing selection acting on the regulatory regions are reported.