Diego Ruano

TL;DR: The results demonstrated an early induction of the a5 subunit expression (at mRNA and protein levels) during the first postnatal week, peaking at P5 and decreasing after this age, which may precede the GABAergic synaptogenesis.

TL;DR: It is shown that in vivo administration of a peptide that activates the PI3K signaling pathway increases spine density in the rat hippocampus and enhances the animals’ cognitive abilities, while in vivo electrophysiological recordings show thatPI3K activation results in synaptic enhancement of Schaffer and stratum lacunosum moleculare inputs.

TL;DR: Quantitative autoradiographic analysis of [3H]zolpidem binding to coronal brain sections from adult and aged Fischer 344 rats demonstrated that the aging‐associated increases in the density of type I (ω1) binding sites were restricted to the hippocampus.

TL;DR: In vivo assays showed that after LPS-injection, iNOS expression was more intense in substantia nigra, a brain area showing specific susceptibility to neurodegeneration after microglia activation, whereas IL-10expression was more sustained in striatum, an area resistant to damage, support that microglial density is pivotal to control the balance between pro- and anti-inflammatory factors release.

TL;DR: A gradient of maturation between the different fields of the hippocampus proper (CA2-3 preceded to CA1 and DG) could be related to the high expression of CR positive cells and fibers during the first 10 postnatal days.