D
Diego Ruano
Researcher at University of Seville
Publications - 60
Citations - 9428
Diego Ruano is an academic researcher from University of Seville. The author has contributed to research in topics: GABAA receptor & Protein subunit. The author has an hindex of 31, co-authored 60 publications receiving 7902 citations. Previous affiliations of Diego Ruano include Centre national de la recherche scientifique & Spanish National Research Council.
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Journal ArticleDOI
Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus
Raquel Sanchez-Varo,Laura Trujillo-Estrada,Elisabeth Sanchez-Mejias,Manuel Torres,Manuel Torres,David Baglietto-Vargas,Ines Moreno-Gonzalez,Vanessa De Castro,Sebastian Jimenez,Sebastian Jimenez,Diego Ruano,Diego Ruano,Marisa Vizuete,Marisa Vizuete,Jose Carlos Davila,José Manuel García-Verdugo,Antonio J. Jiménez,Javier Vitorica,Javier Vitorica,Antonia Gutierrez +19 more
TL;DR: These early abnormalities in axonal and presynaptic structures might represent the morphological substrate of hippocampal dysfunction preceding synaptic and neuronal loss and could significantly contribute to AD pathology in the preclinical stages.
Journal ArticleDOI
Age-dependent Accumulation of Soluble Amyloid β (Aβ) Oligomers Reverses the Neuroprotective Effect of Soluble Amyloid Precursor Protein-α (sAPPα) by Modulating Phosphatidylinositol 3-Kinase (PI3K)/Akt-GSK-3β Pathway in Alzheimer Mouse Model *
Sebastian Jimenez,Manuel Torres,Manuel Torres,Marisa Vizuete,Marisa Vizuete,Raquel Sanchez-Varo,Elisabeth Sanchez-Mejias,Laura Trujillo-Estrada,Irene Carmona-Cuenca,Irene Carmona-Cuenca,Cristina Caballero,Cristina Caballero,Diego Ruano,Diego Ruano,Antonia Gutierrez,Javier Vitorica,Javier Vitorica +16 more
TL;DR: The age-dependent appearance of APP-derived soluble factors modulated the PI3K/Akt/GSK-3β signaling pathway through the major neurotrophin receptors and might provide insights into the selective vulnerability of specific neuronal groups in Alzheimer disease.
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Kainate receptor subunits expressed in single cultured hippocampal neurons: Molecular and functional variants by RNA editing
TL;DR: It is shown that the Q/R site from the GluR6 subunit controls functional properties of native kainate receptors, and that edited and unedited variants may coexist in the same cell.
Journal ArticleDOI
Rat hippocampal GABAergic molecular markers are differentially affected by ageing.
TL;DR: Age‐dependent differential reduction of specific hippocampal inteneuronal subpopulations might produce functional alterations in the GABAergic tone which might be compensated, at the post‐synaptic level, by up‐regulation of the expression of the α1 GABAA receptor subunit.
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Comparative autoradiographic distribution of central ω (benzodiazepine) modulatory site subtypes with high, intermediate and low affinity for zolpidem and alpidem
TL;DR: In adult rat hippocampus, zolpidem and alpidem were found to discriminate between three central omega site subtypes which display high microM affinity, and in neonatal rat CNS, CL 218,872 discriminated between omega 1 and omega 2 sites but not between two omega 2 receptor subpopulations.