Diego Russo

TL;DR: BRAF V600E mutation in PTCs is associated with reduced expression of key genes involved in iodine metabolism, which may alter the effectiveness of diagnostic and/or therapeutic use of radioiodine in BRAF-mut P TCs.

TL;DR: The present review will describe the biological effects of oleuropein and hydroxytyrosol, with particular attention on the molecular mechanism underlying the protective action on cardiovascular and metabolic alterations, as demonstrated by in vitro and in vivo experimental studies performed with the isolated compounds.

TL;DR: Several studies have demonstrated a decrease in or a loss in NIS expression in primary human thyroid carcinomas, and immunohistochemical studies have confirmed this considerably decreased expression of the NIS protein in thyroid cancer tissues, suggesting that the low expression of NIS may represent an early abnormality in the pathway of thyroid cell transformation, rather than being a consequence of cancer progression.

TL;DR: It is suggested that the middle region and carboxyl half of the extracellular domain of the TSH receptor are involved in signal transduction and that the T SH-binding region is likely to span the entire extracllular domain, with multiple discontinuous contact sites.

TL;DR: The genetic analysis resulted more sensitive and accurate than both the cytological analysis and the thyroglobulin measurement in the aspirates, and may provide a useful tool for diagnosis and follow-up of thyroid cancer.