Roberta Morisi

TL;DR: BRAF V600E mutation in PTCs is associated with reduced expression of key genes involved in iodine metabolism, which may alter the effectiveness of diagnostic and/or therapeutic use of radioiodine in BRAF-mut P TCs.

TL;DR: Notch signaling is involved in the determination of thyroid cell fate and is a direct regulator of thyroid-specific gene expression and its deregulation may contribute to the loss of differentiation associated with thyroid tumorigenesis.

TL;DR: The data represent the first demonstration in human thyroid tissues that TSH contributes to the regulation of thyrocyte differentiation by modulating thyroid gene levels.

TL;DR: Results suggest that this novel tyrosine kinase inhibitor may be useful for the treatment of MTC, when confirmed in other in vivo preclinical models.

TL;DR: It is demonstrated that extracellular ATP has a mitogenic effect on ARO cells, increasing ERK phosphorylation, AP1 activation, and cyclin D1 expression, and using the ATP/ADPase apyrase and the P2 receptor antagonist suramin, it exerts mitogenic effects.