Emanuele Tosi

TL;DR: BRAF V600E mutation in PTCs is associated with reduced expression of key genes involved in iodine metabolism, which may alter the effectiveness of diagnostic and/or therapeutic use of radioiodine in BRAF-mut P TCs.

TL;DR: Specific microRNA expression patterns which distinguish medulloblastoma differing in histotypes, in molecular features and in disease‐risk stratification are identified, and misregulated microRNAs expression profiles characterize human medullOBlastomas, and may provide potential targets for novel therapeutic strategies.

TL;DR: Control of NIS expression by inhibition of HDAC appears not to be mediated by cell-specific mechanisms, suggesting it as a potential strategy to induce radioiodine sensitivity in different human tumors.

TL;DR: Notch signaling is involved in the determination of thyroid cell fate and is a direct regulator of thyroid-specific gene expression and its deregulation may contribute to the loss of differentiation associated with thyroid tumorigenesis.

TL;DR: The data represent the first demonstration in human thyroid tissues that TSH contributes to the regulation of thyrocyte differentiation by modulating thyroid gene levels.