D
Dierk Niessing
Researcher at University of Ulm
Publications - 79
Citations - 2875
Dierk Niessing is an academic researcher from University of Ulm. The author has contributed to research in topics: RNA-binding protein & RNA. The author has an hindex of 27, co-authored 70 publications receiving 2400 citations. Previous affiliations of Dierk Niessing include Protein Sciences & Rockefeller University.
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Journal ArticleDOI
Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation
Mario Hofweber,Saskia Hutten,Benjamin Bourgeois,Emil Spreitzer,Annika Niedner-Boblenz,Martina Schifferer,Martina Schifferer,Marc-David Ruepp,Mikael Simons,Mikael Simons,Dierk Niessing,Dierk Niessing,Tobias Madl,Dorothee Dormann +13 more
TL;DR: It is shown that Transportin and arginine methylation have a crucial function beyond nuclear import-namely to suppress RGG/RG-driven phase separation and stress granule association of FUS.
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RNA binding and translational suppression by bicoid
TL;DR: It is reported that bed binds through its homeodomain to cad mRNA in vitro, and exerts translational control through a bed-binding region of cad mRNA.
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Bicoid associates with the 5'-cap-bound complex of caudal mRNA and represses translation.
TL;DR: A novel mode of translational repression is suggested, which combines the strategy of target-specific binding to 3'-untranslated sequences and interference with 5'-cap-dependent translation initiation in one protein.
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Structural features of Argonaute–GW182 protein interactions
Janina Pfaff,Janosch Hennig,Franz Herzog,Ruedi Aebersold,Michael Sattler,Dierk Niessing,Gunter Meister +6 more
TL;DR: The interaction of Ago proteins with GW proteins is characterized in molecular detail and it is shown that only a subset of Trp residues engage in Ago interactions, which indicates that the Ago–GW protein interaction might be a two-step process involving the sequential binding of two tryptophans separated by a spacer with a minimal length of 10 aa.
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A Cytoplasmic Complex Mediates Specific mRNA Recognition and Localization in Yeast
Marisa Müller,Roland Gerhard Heym,Andreas Mayer,Katharina Kramer,Maria Schmid,Patrick Cramer,Henning Urlaub,Ralf-Peter Jansen,Dierk Niessing +8 more
TL;DR: The localization of ash mRNA in yeast requires the binding of She2p and the myosin adaptor protein She3p to its localization element, which is highly specific and leads to the assembly of stable transport complexes.