G
Gunter Meister
Researcher at University of Regensburg
Publications - 190
Citations - 25335
Gunter Meister is an academic researcher from University of Regensburg. The author has contributed to research in topics: Argonaute & microRNA. The author has an hindex of 65, co-authored 176 publications receiving 22760 citations. Previous affiliations of Gunter Meister include Rockefeller University & Dresden University of Technology.
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Journal ArticleDOI
Mechanisms of gene silencing by double-stranded RNA
Gunter Meister,Thomas Tuschl +1 more
TL;DR: A key step in known silencing pathways is the processing of dsRNAs into short RNA duplexes of characteristic size and structure, which guide RNA silencing by specific and distinct mechanisms.
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Human Argonaute2 Mediates RNA Cleavage Targeted by miRNAs and siRNAs
Gunter Meister,Markus Landthaler,Agnieszka Patkaniowska,Yair Dorsett,Grace Teng,Thomas Tuschl +5 more
TL;DR: In this paper, it was shown that miRNAs are incorporated indiscriminately of their sequence into Ago1 through Ago4 containing microRNPs (miRNPs) and endonuclease activity is exclusively associated with Ago2.
Journal Article
Human argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs
Gunter Meister,Markus Landthaler,Agnieszka Patkaniowska,Yair Dorsett,Grace Teng,Thomas Tuschl +5 more
TL;DR: The authors' results suggest that miRNAs are incorporated indiscriminately of their sequence into Ago1 through Ago4 containing microRNPs (miRNPs), and the specific role of Ago2 in guiding target RNA cleavage was confirmed by siRNA-based depletion of individual Ago members in combination with a sensitive positive-readout reporter assay.
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Differential Regulation of microRNAs by p53 Revealed by Massively Parallel Sequencing: miR-34a is a p53 Target That Induces Apoptosis and G1-arrest
Valery Tarasov,Peter Jung,Berlinda Verdoodt,Dmitri Lodygin,Alexey Epanchintsev,Antje Menssen,Gunter Meister,Heiko Hermeking +7 more
TL;DR: The authors' results for the first time directly integrate the regulation of miRNA expression into the transcriptional network regulated by p53, and siRNAs corresponding to p53‑induced miRNAs may have potential as cancer therapeutic agents as RNA interference based therapies are currently emerging.
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Argonaute proteins: functional insights and emerging roles
TL;DR: This work has made progress in the understanding of classical Argonaute-mediated gene-silencing principles, such as the effects on mRNA translation and decay, but has also implicatedArgonaute proteins in several other cellular processes,such as transcriptional regulation and splicing.