M
Mikael Simons
Researcher at German Center for Neurodegenerative Diseases
Publications - 149
Citations - 23338
Mikael Simons is an academic researcher from German Center for Neurodegenerative Diseases. The author has contributed to research in topics: Myelin & Oligodendrocyte. The author has an hindex of 62, co-authored 138 publications receiving 18555 citations. Previous affiliations of Mikael Simons include Heidelberg University & Max Planck Society.
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Journal ArticleDOI
Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes
Katarina Trajkovic,Chieh Hsu,Salvatore Chiantia,Lawrence Rajendran,Dirk Wenzel,Felix T. Wieland,Petra Schwille,Britta Brügger,Mikael Simons +8 more
TL;DR: It is found that cargo is segregated into distinct subdomains on the endosomal membrane and that the transfer of exosome-associated domains into the lumen of theendosome did not depend on the function of the ESCRT (endosomal sorting complex required for transport) machinery, but required the sphingolipid ceramide.
Journal ArticleDOI
Exosomes--vesicular carriers for intercellular communication.
Mikael Simons,Graça Raposo +1 more
TL;DR: Exosomes transfer not only membrane components but also nucleic acid between different cells, emphasizing their role in intercellular communication.
Journal ArticleDOI
Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity.
Ludovico Cantuti-Castelvetri,Ludovico Cantuti-Castelvetri,Ravi Ojha,Liliana D. Pedro,Liliana D. Pedro,Minou Djannatian,Minou Djannatian,Jonas Franz,Suvi Kuivanen,Franziska van der Meer,Katri Kallio,Tuğberk Kaya,Tuğberk Kaya,Tuğberk Kaya,Maria Anastasina,Maria Anastasina,Teemu Smura,Lev Levanov,Leonora Szirovicza,Allan Tobi,Hannimari Kallio-Kokko,Pamela Österlund,Merja Joensuu,Frederic A. Meunier,Sarah J. Butcher,Sarah J. Butcher,Martin Sebastian Winkler,Brit Mollenhauer,Ari Helenius,Ozgun Gokce,Tambet Teesalu,Tambet Teesalu,Tambet Teesalu,Jussi Hepojoki,Jussi Hepojoki,Olli Vapalahti,Christine Stadelmann,Giuseppe Balistreri,Giuseppe Balistreri,Mikael Simons,Mikael Simons +40 more
TL;DR: It is found that neuropilin-1 (NRP1), known to bind furin-cleaved substrates, significantly potentiates SARS-CoV-2 infectivity, an effect blocked by a monoclonal blocking antibody against NRP1.
Journal ArticleDOI
Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons.
TL;DR: It is shown that cholesterol is required for Abeta formation to occur and imply a link between cholesterol, Abeta, and Alzheimer's disease.
Journal ArticleDOI
Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo
Klaus Fassbender,Mikael Simons,C. Bergmann,Mark Stroick,Dieter Lütjohann,Patrick Keller,Heiko Runz,Sandra Kühl,Thomas Bertsch,K. von Bergmann,M. Hennerici,Konrad Beyreuther,Tobias Hartmann +12 more
TL;DR: It is demonstrated that the widely used cholesterol-lowering drugs simvastatin and lovastatin reduce intracellular and extracellular levels of Aβ42 and Aβ40 peptides in primary cultures of hippocampal neurons and mixed cortical neurons, suggesting that lipids are playing an important role in the development of Alzheimer's disease.