D
Dina Laznik-Bogoslavski
Researcher at Harvard University
Publications - 13
Citations - 2513
Dina Laznik-Bogoslavski is an academic researcher from Harvard University. The author has contributed to research in topics: Thermogenesis & Adipose tissue. The author has an hindex of 9, co-authored 12 publications receiving 1847 citations.
Papers
More filters
Journal ArticleDOI
Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway
Christiane D. Wrann,James P. White,John Salogiannnis,Dina Laznik-Bogoslavski,Jun Wu,Di Ma,Jiandie D. Lin,Michael E. Greenberg,Bruce M. Spiegelman +8 more
TL;DR: It is shown that FNDC5, a previously identified muscle protein that is induced in exercise and is cleaved and secreted as irisin, is also elevated by endurance exercise in the hippocampus of mice.
Journal ArticleDOI
A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat
Lawrence Kazak,Edward T. Chouchani,Mark P. Jedrychowski,Brian K. Erickson,Kosaku Shinoda,Paul Cohen,Ramalingam Vetrivelan,Gina Z. Lu,Dina Laznik-Bogoslavski,Sebastian C. Hasenfuss,Shingo Kajimura,Steve P. Gygi,Bruce M. Spiegelman +12 more
TL;DR: It is demonstrated that creatine enhances respiration in beige-fat mitochondria when ADP is limiting and decreases whole-body energy expenditure after administration of a β3-agonist and reduces beige and brown adipose metabolic rate.
Journal ArticleDOI
Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1
Edward T. Chouchani,Lawrence Kazak,Mark P. Jedrychowski,Gina Z. Lu,Brian K. Erickson,John Szpyt,Kerry A. Pierce,Dina Laznik-Bogoslavski,Ramalingam Vetrivelan,Clary B. Clish,Alan J. Robinson,Steve P. Gygi,Bruce M. Spiegelman +12 more
TL;DR: Mitochondrial ROS induction in brown adipose tissue is identified as a mechanism that supports UCP1-dependent thermogenesis and whole-body energy expenditure, which opens the way to improved therapeutic strategies for combating metabolic disorders.
Journal ArticleDOI
An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ
Alexander S. Banks,Fiona E. McAllister,Joao Paulo Camporez,Peter-James H. Zushin,Michael J. Jurczak,Dina Laznik-Bogoslavski,Gerald I. Shulman,Steven P. Gygi,Bruce M. Spiegelman +8 more
TL;DR: Pharmacological inhibition of MEK and ERK markedly improves insulin resistance in both obese wild-type and ob/ob mice, and also completely reverses the deleterious effects of the Cdk5 ablation, suggesting that MEK/ERK inhibitors may hold promise for the treatment of type 2 diabetes.
Journal ArticleDOI
Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity
Lawrence Kazak,Edward T. Chouchani,Gina Z. Lu,Mark P. Jedrychowski,Curtis J. Bare,Amir I. Mina,Manju Kumari,Song Zhang,Ivan Vuckovic,Dina Laznik-Bogoslavski,Petras P. Dzeja,Alexander S. Banks,Evan D. Rosen,Bruce M. Spiegelman +13 more
TL;DR: Inactivated the first and rate-limiting enzyme of creatine biosynthesis, glycine amidinotransferase (GATM), selectively in fat of Adipo-Gatm KO mice, providing strong in vivo genetic support for a role of GATM and creatine metabolism in energy expenditure, diet-induced thermogenesis, and defense against diet- induced obesity.