Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway
Christiane D. Wrann,James P. White,John Salogiannnis,Dina Laznik-Bogoslavski,Jun Wu,Di Ma,Jiandie D. Lin,Michael E. Greenberg,Bruce M. Spiegelman +8 more
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TLDR
It is shown that FNDC5, a previously identified muscle protein that is induced in exercise and is cleaved and secreted as irisin, is also elevated by endurance exercise in the hippocampus of mice.About:
This article is published in Cell Metabolism.The article was published on 2013-11-05 and is currently open access. It has received 868 citations till now. The article focuses on the topics: Brain-derived neurotrophic factor & Neurotrophic factors.read more
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Journal ArticleDOI
Integrative Biology of Exercise
John A. Hawley,John A. Hawley,Mark Hargreaves,Michael J. Joyner,Juleen R. Zierath,Juleen R. Zierath +5 more
TL;DR: The application of molecular techniques to exercise biology has provided greater understanding of the multiplicity and complexity of cellular networks involved in exercise responses, and recent discoveries offer perspectives on the mechanisms by which muscle "communicates" with other organs and mediates the beneficial effects of exercise on health and performance.
Journal ArticleDOI
Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis
Rajesh R. Rao,Jonathan Z. Long,James P. White,Katrin J. Svensson,Jesse Lou,Isha A. Lokurkar,Mark P. Jedrychowski,Jorge L. Ruas,Christiane D. Wrann,James C. Lo,Donny M. Camera,Jenn Lachey,Steven P. Gygi,Jasbir Seehra,John A. Hawley,Bruce M. Spiegelman +15 more
TL;DR: The identification of meteorin-like (Metrnl), a circulating factor that is induced in muscle after exercise and in adipose tissue upon cold exposure, which links host-adaptive responses to the regulation of energy homeostasis and tissue inflammation and has therapeutic potential for metabolic and inflammatory diseases.
Journal ArticleDOI
Irisin and FGF21 Are Cold-Induced Endocrine Activators of Brown Fat Function in Humans
Paul R. Lee,Joyce D. Linderman,Sheila Smith,Robert J. Brychta,Juan Wang,Christopher Idelson,Rachel M. Perron,Charlotte D. Werner,Giao Q. Phan,Udai S. Kammula,Electron Kebebew,Karel Pacak,Kong Y. Chen,Francesco S. Celi +13 more
TL;DR: Results suggest exercise-induced irisin secretion could have evolved from shivering-related muscle contraction, serving to augment brown fat thermogenesis in concert with FGF21, a brown adipokine in rodents.
Journal ArticleDOI
Skeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression
Leandro Z. Agudelo,Teresa Femenía,Funda Orhan,Margareta Porsmyr-Palmertz,Michel Goiny,Vicente Martínez-Redondo,Jorge C. Correia,Manizheh Izadi,Maria Bhat,Maria Bhat,Ina Schuppe-Koistinen,Ina Schuppe-Koistinen,Amanda T. Pettersson,Duarte M. S. Ferreira,Anna Krook,Romain Barrès,Juleen R. Zierath,Sophie Erhardt,Maria Lindskog,Jorge L. Ruas +19 more
TL;DR: A mechanism by which skeletal muscle PGC-1α1 induced by exercise training changes kynurenine metabolism and protects from stress-induced depression is described, opening therapeutic avenues for the treatment of depression by targeting the P GC-1β-PPAR axis in skeletal muscle, without the need to cross the blood-brain barrier.
Journal ArticleDOI
Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model
Se Hoon Choi,Enjana Bylykbashi,Zena K. Chatila,Star W. Lee,Benjamin Pulli,Gregory D. Clemenson,Eunhee Kim,Alexander Rompala,Mary K. Oram,Caroline Asselin,Jenna Aronson,Can Zhang,Sean J. Miller,Andrea N. Lesinski,John W. Chen,Doo Yeon Kim,Henriette van Praag,Bruce M. Spiegelman,Fred H. Gage,Rudolph E. Tanzi +19 more
TL;DR: Exercise-induced AHN improved cognition along with reduced Aβ load and increased levels of brain-derived neurotrophic factor (BDNF), interleukin-6 (IL-6), fibronectin type III domain–containing protein–5 (FNDC5), and synaptic markers, however, AHN activation was also required for exercise-induced improvement in memory.
References
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A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis.
Pere Puigserver,Zhidan Wu,Cheol Won Park,Reed A. Graves,Margaret E. Wright,Bruce M. Spiegelman +5 more
TL;DR: Results indicate that PGC-1 plays a key role in linking nuclear receptors to the transcriptional program of adaptive thermogenesis.
Journal ArticleDOI
The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
Michael F. Egan,Masami Kojima,Masami Kojima,Joseph H. Callicott,Terry E. Goldberg,Bhaskar Kolachana,Alessandro Bertolino,Eugene Zaitsev,Bert Gold,David Goldman,Michael Dean,Bai Lu,Daniel R. Weinberger +12 more
TL;DR: A role is demonstrated for BDNF and its val/met polymorphism in human memory and hippocampal function and it is suggested val/ met exerts these effects by impacting intracellular trafficking and activity-dependent secretion of BDNF.
Journal ArticleDOI
Fitness Effects on the Cognitive Function of Older Adults: A Meta-Analytic Study
TL;DR: Fitness training was found to have robust but selective benefits for cognition, with the largest fitness-induced benefits occurring for executive-control processes.
Journal ArticleDOI
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Pontus Boström,Jun Wu,Mark P. Jedrychowski,Anisha Korde,Li Ye,James C. Lo,Kyle A. Rasbach,Elisabeth A. Boström,Jang Hyun Choi,Jonathan Z. Long,Shingo Kajimura,Maria Cristina Zingaretti,Birgitte F. Vind,Hua Tu,Saverio Cinti,Kurt Højlund,Steven P. Gygi,Bruce M. Spiegelman +17 more
TL;DR: This article showed that PGC1α expression in muscle stimulates an increase in expression of FNDC5, a membrane protein that is cleaved and secreted as a newly identified hormone, irisin.
Journal ArticleDOI
Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
Jun Wu,Pontus Boström,Lauren M. Sparks,Li Ye,Jang Hyun Choi,An Hoa Giang,Melin J. Khandekar,Kirsi A. Virtanen,Pirjo Nuutila,Gert Schaart,Kexin Huang,Hua Tu,Wouter D. van Marken Lichtenbelt,Joris Hoeks,Sven Enerbäck,Patrick Schrauwen,Bruce M. Spiegelman +16 more
TL;DR: Beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin, providing evidence that previously identified brown fat deposits in adult humans are composed of beige adipocytes.
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