Steve P. Gygi

TL;DR: It is demonstrated that creatine enhances respiration in beige-fat mitochondria when ADP is limiting and decreases whole-body energy expenditure after administration of a β3-agonist and reduces beige and brown adipose metabolic rate.

TL;DR: Mitochondrial ROS induction in brown adipose tissue is identified as a mechanism that supports UCP1-dependent thermogenesis and whole-body energy expenditure, which opens the way to improved therapeutic strategies for combating metabolic disorders.

TL;DR: A large-scale phosphorylation analysis of alpha-factor-arrested yeast yielded the confident identification of 2288 nonredundant phosphorylated sites from 985 proteins, and a large number of members of the pheromone signaling pathway were found as phosphoproteins and are discussed.

TL;DR: The physical and functional interactions among SMN, FUS, TDP-43, and Gems indicate that ALS and SMA share a biochemical pathway, providing strong support for the view that these motor neuron diseases are related.

TL;DR: It is shown that ER stress and glucose deprivation stimulate mitochondrial bioenergetics and formation of respiratory supercomplexes (SCs) through protein kinase R-like ER kinase (PERK), and PERK activation is sufficient to rescue bioenergetic defects caused by complex I missense mutations derived from mitochondrial disease patients.