D
Dina Stroopinsky
Researcher at Beth Israel Deaconess Medical Center
Publications - 62
Citations - 1241
Dina Stroopinsky is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: T cell & Leukemia. The author has an hindex of 16, co-authored 51 publications receiving 936 citations. Previous affiliations of Dina Stroopinsky include Technion – Israel Institute of Technology & Rambam Health Care Campus.
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Journal ArticleDOI
Lenalidomide enhances anti-myeloma cellular immunity
Katarina Luptakova,Jacalyn Rosenblatt,Brett Glotzbecker,Heidi Mills,Dina Stroopinsky,Turner Kufe,Baldev Vasir,Jon E. Arnason,Dimitri Tzachanis,Jeffrey I. Zwicker,Robin Joyce,James D. Levine,Kenneth C. Anderson,Donald Kufe,David Avigan +14 more
TL;DR: It is demonstrated that exposure to lenalidomide in the context of T-cell expansion with direct ligation of CD3/CD28 complex results in polarization toward a Th1 phenotype characterized by increased IFN-γ, but not IL-10 expression, and thereby augmenting responses to a myeloma-specific tumor vaccine.
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Individualized vaccination of AML patients in remission is associated with induction of antileukemia immunity and prolonged remissions.
Jacalyn Rosenblatt,Richard Stone,Lynne Uhl,Donna Neuberg,Robin Joyce,James D. Levine,Jon E. Arnason,Malgorzata McMasters,Katarina Luptakova,Salvia Jain,Jeffrey I. Zwicker,Ayad Hamdan,Vassiliki A. Boussiotis,David P. Steensma,Daniel J. DeAngelo,Ilene Galinsky,Poorvi Somaiya Dutt,Emma Logan,Mary Paty Bryant,Dina Stroopinsky,Lillian Werner,Kristen Palmer,Max Coll,Abigail Washington,Leandra Cole,Donald Kufe,David Avigan +26 more
TL;DR: The results demonstrate that personalized vaccination of AML patients in remission induces the expansion of leukemia-specific T cells and may be protective against disease relapse.
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MUC1-mediated induction of myeloid-derived suppressor cells in patients with acute myeloid leukemia
Athalia Rachel Pyzer,Dina Stroopinsky,Hasan Rajabi,Abigail Washington,Ashujit Tagde,Maxwell D. Coll,Jacqueline Fung,Mary Paty Bryant,Leandra Cole,Kristen Palmer,Poorvi Somaiya,Rebecca Karp Leaf,Myrna Nahas,Arie Apel,Salvia Jain,Malgorzata McMasters,Lourdes M. Mendez,James D. Levine,Robin Joyce,Jon E. Arnason,Pier Paolo Pandolfi,Donald Kufe,Jacalyn Rosenblatt,David Avigan +23 more
TL;DR: It is demonstrated that AML EVs are taken-up myeloid progenitor cells, resulting in the selective proliferation of MDSCs in comparison with functionally competent antigen-presenting cells, and the microRNA miR34a acts as the regulatory mechanism by which MUC1 drives c-myc expression in AML cells and EVs.
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Epstein−Barr virus-encoded EBNA2 alters immune checkpoint PD-L1 expression by downregulating miR-34a in B-cell lymphomas
Eleni Anastasiadou,Dina Stroopinsky,Stella Alimperti,Alan L Jiao,Athalia Rachel Pyzer,Claudia Cippitelli,Giuseppina Pepe,Martina Severa,Jacalyn Rosenblatt,Marilena P. Etna,Simone Rieger,Bettina Kempkes,Eliana M. Coccia,Shannan J. Ho Sui,Christopher S. Chen,Stefania Uccini,David Avigan,Alberto Faggioni,Pankaj Trivedi,Frank J. Slack +19 more
TL;DR: It is found that latency III-expressing Burkitt lymphoma, diffuse large B-cell lymphomas, or their EBNA2-transfected derivatives express high PD-L1, and early B- cell factor 1 (EBF1) is identified as a repressor of miR-34a transcription.
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Dynamic analysis of immune and cancer cell interactions at single cell level in microfluidic droplets.
Saheli Sarkar,Pooja Sabhachandani,Dina Stroopinsky,Kristen Palmer,Noa Cohen,Jacalyn Rosenblatt,David Avigan,Tania Konry +7 more
TL;DR: The results suggest that the droplet array-based microfluidic platform is a powerful technique for dynamic phenotypic screening and potentially applicable for evaluation of novel cell-based immunotherapeutic agents.