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Alan L Jiao
Researcher at Beth Israel Deaconess Medical Center
Publications - 10
Citations - 326
Alan L Jiao is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: microRNA & Gene. The author has an hindex of 6, co-authored 9 publications receiving 238 citations. Previous affiliations of Alan L Jiao include Yale University & Harvard University.
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Journal ArticleDOI
Epstein−Barr virus-encoded EBNA2 alters immune checkpoint PD-L1 expression by downregulating miR-34a in B-cell lymphomas
Eleni Anastasiadou,Dina Stroopinsky,Stella Alimperti,Alan L Jiao,Athalia Rachel Pyzer,Claudia Cippitelli,Giuseppina Pepe,Martina Severa,Jacalyn Rosenblatt,Marilena P. Etna,Simone Rieger,Bettina Kempkes,Eliana M. Coccia,Shannan J. Ho Sui,Christopher S. Chen,Stefania Uccini,David Avigan,Alberto Faggioni,Pankaj Trivedi,Frank J. Slack +19 more
TL;DR: It is found that latency III-expressing Burkitt lymphoma, diffuse large B-cell lymphomas, or their EBNA2-transfected derivatives express high PD-L1, and early B- cell factor 1 (EBF1) is identified as a repressor of miR-34a transcription.
Journal ArticleDOI
RNA-mediated gene activation.
Alan L Jiao,Frank J. Slack +1 more
TL;DR: The current knowledge of gene activation by smallRNAs, long non-coding RNAs, and enhancer-derived RNAs is summarized, with an emphasis on epigenetic mechanisms.
Journal ArticleDOI
MUC1 inhibition leads to decrease in PD-L1 levels via upregulation of miRNAs
Athalia Rachel Pyzer,Dina Stroopinsky,Jacalyn Rosenblatt,Eleni Anastasiadou,Hasan Rajabi,Abigail Washington,Ashujit Tagde,Jen-Hwa Chu,Maxwell D. Coll,Alan L Jiao,LT Tsai,Danielle Tenen,Leandra Cole,Kristen Palmer,Adam Ephraim,Rebecca Karp Leaf,Myrna Nahas,Arie Apel,Michal Bar-Natan,Salvia Jain,Malgorzata McMasters,Lourdes M. Mendez,Jon E. Arnason,Benjamin A. Raby,Frank J. Slack,Donald Kufe,David Avigan +26 more
TL;DR: Findings suggest MUC1 is a critical regulator of PD-L1 expression via its effects on microRNA levels and represents a potential therapeutic target to enhance anti-tumor immunity.
Journal ArticleDOI
Autoregulation of lin-4 microRNA transcription by RNA activation (RNAa) in C. elegans
TL;DR: The first in vivo evidence of RNA activation (RNAa) by an endogenous miRNA is described, and new insights are provided into an elegant autoregulatory mechanism that ensures the proper timing of stem cell fate decisions in development.
Journal ArticleDOI
Analysis of m6A RNA methylation in Caenorhabditis elegans .
Erdem Sendinc,David Valle-Garcia,David Valle-Garcia,David Valle-Garcia,Alan L Jiao,Alan L Jiao,Yang Shi,Yang Shi +7 more
TL;DR: To gain insights into how this modification is installed in this organism, a targeted RNAi screen was designed by which the expression of 22 candidate RNA methyltransferase genes were knocked down and resulted in a decrease in global m6A level in total RNA.