Dirk A. E. Dobbelaere

TL;DR: Theileria annulata and T. parva-infected lymphoblastoid cells were examined for their capacity to produce interferon (IFN) and antiviral activity and the importance of IFN for the pathogenesis of theileriosis is discussed.

TL;DR: This study shows that CLASP1, an MT-stabilizing protein that plays important roles in regulating kinetochore-MT attachment and central spindle positioning, is sequestered at the Theileria annulata schizont surface and describes for the first time TA03615, a Theilaria protein which localizes to the parasite surface, where it has the potential to participate in parasite-host interactions.

TL;DR: Studies using inhibitors and dominant negative mutants demonstrate that the parasite activates a NF-kappaB-dependent anti-apoptotic mechanism that protects the transformed cell form spontaneous apoptosis and is essential for maintaining the transformed state of the parasitised cell.

TL;DR: Analysis of the susceptibility of different cell lines and purified populations of lymphocytes to infection and transformation by both isolates showed that T. parva Chitongo-transformed target cells were exclusively infected CD8+ lymphocytes, suggesting a role of cell tropism in virulence.

TL;DR: It is demonstrated that chloramphenicol-induced merogony is inherently asynchronous and has a quantitative basis, supporting postulation that the differentiation event is a stochastic process that can be manipulated to alter the outcome of parasitic infection.