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Ditte Hededam Welner
Researcher at Technical University of Denmark
Publications - 32
Citations - 1439
Ditte Hededam Welner is an academic researcher from Technical University of Denmark. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 11, co-authored 22 publications receiving 1083 citations. Previous affiliations of Ditte Hededam Welner include Statens Serum Institut & Joint BioEnergy Institute.
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Journal ArticleDOI
Stimulation of lignocellulosic biomass hydrolysis by proteins of glycoside hydrolase family 61: structure and function of a large, enigmatic family
Paul Harris,Ditte Hededam Welner,Keith Mcfarland,Edward Re,Jens-Christian N. Poulsen,Kimberly Brown,Rune Salbo,Hanshu Ding,Elena Vlasenko,Sandy Merino,Feng Xu,Joel R. Cherry,Sine Larsen,Leila Lo Leggio +13 more
TL;DR: It is shown that certain GH61 proteins lack measurable hydrolytic activity but in the presence of various divalent metal ions can significantly reduce the total protein loading required to hydrolyze lignocellulosic biomass, and it is concluded that the GH 61 proteins are unlikely to be glycoside hydrolases.
Journal ArticleDOI
Employing a biochemical protecting group for a sustainable indigo dyeing strategy.
Tammy Melody Hsu,Ditte Hededam Welner,Zachary N. Russ,Bernardo Cervantes,Ramya Lakshmi Prathuri,Paul D. Adams,Paul D. Adams,Paul D. Adams,John E. Dueber,John E. Dueber +9 more
TL;DR: A sustainable dyeing strategy that not only circumvents the use of toxic reagents for indigo chemical synthesis but also removes the need for a reducing agent for dye solubilization is described.
Journal ArticleDOI
Evolution-guided engineering of small-molecule biosensors
Tim Snoek,Evan K. Chaberski,Francesca Ambri,Stefan Kol,Sara Petersen Bjørn,Bo Pang,Jesus F. Barajas,Ditte Hededam Welner,Michael Krogh Jensen,Jay D. Keasling +9 more
TL;DR: This work presents a versatile and high-throughput method to evolve prokaryotic aTF specificity and transfer functions in a eukaryote chassis, namely baker's yeast Saccharomyces cerevisiae, and robustly select aTF variants of the cis,cis-muconic acid-inducible transcription factor BenM evolved.
Journal ArticleDOI
DNA binding by the plant-specific NAC transcription factors in crystal and solution: a firm link to WRKY and GCM transcription factors.
Ditte Hededam Welner,Søren Lindemose,J. Günter Grossmann,Niels Erik Møllegaard,Addie Nina Olsen,Charlotte Helgstrand,Karen Skriver,Leila Lo Leggio +7 more
TL;DR: Experimental evidence is provided for the speculated relationship between plant-specific NAC proteins, WRKY transcription factors and the mammalian GCM (Glial cell missing) transcription factors, which all use a β-strand motif for DNA-binding.
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A structural overview of GH61 proteins - fungal cellulose degrading polysaccharide monooxygenases.
TL;DR: This mini-review focuses on the contribution that structure elucidation has made in the understanding of GH61 molecular function and reviews the currently known structures and the challenges remaining ahead for exploiting this new class of enzymes to the full.