P
Paul Harris
Researcher at Novozymes
Publications - 61
Citations - 4846
Paul Harris is an academic researcher from Novozymes. The author has contributed to research in topics: Polynucleotide & Nucleic acid. The author has an hindex of 22, co-authored 61 publications receiving 4499 citations.
Papers
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Journal ArticleDOI
Genome sequencing and analysis of the biomass-degrading fungus Trichoderma reesei (syn. Hypocrea jecorina).
Diego Martinez,Diego Martinez,Randy M. Berka,Bernard Henrissat,Markku Saloheimo,Mikko Arvas,Scott E. Baker,Jarod Chapman,Olga Chertkov,Pedro M. Coutinho,Dan Cullen,Etienne Danchin,Igor V. Grigoriev,Paul Harris,Melissa Jackson,Christian P. Kubicek,Cliff Han,Isaac Ho,Luis F. Larrondo,Alfredo Lopez de Leon,Jon K. Magnuson,Sandy Merino,Monica Misra,Beth Nelson,Nicholas H. Putnam,Barbara Robbertse,Asaf Salamov,Monika Schmoll,Astrid Terry,Nina Thayer,Ann Westerholm-Parvinen,Conrad L. Schoch,Jian Yao,Ravi D. Barabote,Mary Anne Nelson,Chris Detter,David Bruce,Cheryl R. Kuske,Gary Xie,Paul G. Richardson,Daniel S. Rokhsar,Susan Lucas,Edward M. Rubin,Nigel Dunn-Coleman,Michael Ward,Thomas Brettin +45 more
TL;DR: This work assembled 89 scaffolds to generate 34 Mbp of nearly contiguous T. reesei genome sequence comprising 9,129 predicted gene models, providing a roadmap for constructing enhanced T.Reesei strains for industrial applications such as biofuel production.
Journal ArticleDOI
Stimulation of lignocellulosic biomass hydrolysis by proteins of glycoside hydrolase family 61: structure and function of a large, enigmatic family
Paul Harris,Ditte Hededam Welner,Keith Mcfarland,Edward Re,Jens-Christian N. Poulsen,Kimberly Brown,Rune Salbo,Hanshu Ding,Elena Vlasenko,Sandy Merino,Feng Xu,Joel R. Cherry,Sine Larsen,Leila Lo Leggio +13 more
TL;DR: It is shown that certain GH61 proteins lack measurable hydrolytic activity but in the presence of various divalent metal ions can significantly reduce the total protein loading required to hydrolyze lignocellulosic biomass, and it is concluded that the GH 61 proteins are unlikely to be glycoside hydrolases.
Journal ArticleDOI
Genome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion
Diego Martinez,Diego Martinez,Jean F. Challacombe,Ingo Morgenstern,David S. Hibbett,Monika Schmoll,Christian P. Kubicek,Patricia Ferreira,Francisco J. Ruiz-Dueñas,Ángel T. Martínez,Phil Kersten,Kenneth E. Hammel,Amber Vanden Wymelenberg,Jill Gaskell,Erika Lindquist,Grzegorz Sabat,Sandra Splinter BonDurant,Luis F. Larrondo,Paulo Canessa,Rafael Vicuña,Jagjit S. Yadav,Harshavardhan Doddapaneni,Venkataramanan Subramanian,Antonio G. Pisabarro,José Luis Lavín,José A. Oguiza,Emma R. Master,Bernard Henrissat,Pedro M. Coutinho,Paul Harris,Jon K. Magnuson,Scott E. Baker,Kenneth S. Bruno,William Kenealy,Patrik J. Hoegger,Ursula Kües,Preethi Ramaiya,Susan Lucas,Asaf Salamov,Harris Shapiro,Hank Tu,Christine L. Chee,Monica Misra,Gary Xie,Sarah Teter,Debbie Yaver,Timothy Y. James,Martin Mokrejs,Martin Pospíšek,Igor V. Grigoriev,Thomas Brettin,Daniel S. Rokhsar,Randy M. Berka,Dan Cullen +53 more
TL;DR: Comparisons with the closely relatedwhite-rot fungus Phanerochaete chrysosporium support an evolutionary shift from white-rot to brown-rot during which the capacity for efficient depolymerization of lignin was lost.
Journal ArticleDOI
Comparative genomic analysis of the thermophilic biomass-degrading fungi Myceliophthora thermophila and Thielavia terrestris
Randy M. Berka,Igor V. Grigoriev,Robert Otillar,Asaf Salamov,Jane Grimwood,Ian D. Reid,Nadeeza Ishmael,Tricia John,Corinne Darmond,Marie Claude Moisan,Bernard Henrissat,Pedro M. Coutinho,Vincent Lombard,Donald O. Natvig,Erika Lindquist,Jeremy Schmutz,Susan Lucas,Paul Harris,Justin Powlowski,Annie Bellemare,David Taylor,Gregory Butler,Ronald P. de Vries,Iris E. Allijn,Joost Van Den Brink,Sophia Ushinsky,Reginald Storms,Amy Jo Powell,Ian T. Paulsen,Liam D. H. Elbourne,Scott E. Baker,Jon K. Magnuson,Sylvie Laboissiere,A. John Clutterbuck,Diego Martinez,Diego Martinez,Mark Wogulis,Alfredo Lopez de Leon,Michael Rey,Adrian Tsang +39 more
TL;DR: These genomes are the first described for thermophilic eukaryotes and the first complete telomere-to-telomere genomes for filamentous fungi and suggest that both thermophiles are capable of hydrolyzing all major polysaccharides found in biomass.
Patent
Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
TL;DR: In this article, isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polyptides have been described, which relates to nucleic acid constructs, vectors, and host cells comprising the polyn nucleotides as well as methods of producing and using the poly peptides.