D
Dmitry Goldgaber
Researcher at Stony Brook University
Publications - 54
Citations - 10760
Dmitry Goldgaber is an academic researcher from Stony Brook University. The author has contributed to research in topics: Amyloid beta & Amyloid precursor protein. The author has an hindex of 32, co-authored 54 publications receiving 10401 citations. Previous affiliations of Dmitry Goldgaber include State University of New York System & Duke University.
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Journal ArticleDOI
Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease.
Ann M. Saunders,Warren J. Strittmatter,Donald E. Schmechel,P. St. George-Hyslop,Margaret A. Pericak-Vance,S. H. Joo,B.L. Rosi,James F. Gusella,D. R. Crapper-MacLachlan,Mark J. Alberts,Christine M. Hulette,Barbara J. Crain,Dmitry Goldgaber,A. D. Roses +13 more
TL;DR: Data support the involvement of ApoE ϵ4 in the pathogenesis of late-onset familial and sporadic AD and suggest it may operate as a susceptibility gene (risk factor) for the clinical expression of AD.
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Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease
Donald E. Schmechel,Ann M. Saunders,Warren J. Strittmatter,Barbara J. Crain,Christine M. Hulette,S. H. Joo,Margaret A. Pericak-Vance,Dmitry Goldgaber,A. D. Roses +8 more
TL;DR: In an autopsy series of brains of late-onset AD patients, a strong association of APOE4 allele with increased vascular and plaque A beta deposits is found.
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Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease
Warren J. Strittmatter,Karl H. Weisgraber,David Huang,Li Ming Dong,Guy S. Salvesen,Margaret A. Pericak-Vance,Donald E. Schmechel,Ann M. Saunders,Dmitry Goldgaber,Allen D. Roses +9 more
TL;DR: Differences in the two isoforms in complexing with the beta/A4 peptide may be involved in the pathogenesis of the intra- and extracellular lesions of Alzheimer disease.
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Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells.
Dmitry Goldgaber,H W Harris,Timothy Hla,T Maciag,Robert J. Donnelly,J S Jacobsen,Michael P. Vitek,D. C. Gajdusek +7 more
TL;DR: It is suggested that IL-1 upregulates APP gene expression in HUVEC through a pathway mediated by protein kinase C, utilizing the upstream AP-1 binding site of the APP promoter.
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Apolipoprotein E ∈4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases
Ann M. Saunders,A. D. Roses,Margaret A. Pericak-Vance,K. C. Dole,Warren J. Strittmatter,Donald E. Schmechel,Mari H. Szymanski,N. McCown,M. G. Manwaring,Kenneth E. Schmader,John C.S. Breitner,Dmitry Goldgaber,Merrill D. Benson,L. G. Goldfarb,W. T. Brown +14 more
TL;DR: The frequency of the allele for apolipoprotein E type 4 (epsilon 4) is increased in late-onset familial and sporadic Alzheimer's disease (AD) in patients with amyloid-forming diseases whose epsilon 4 distributions were not previously known.