D
Dolan B. Pritchett
Researcher at University of Pennsylvania
Publications - 37
Citations - 7436
Dolan B. Pritchett is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Receptor & GABAA receptor. The author has an hindex of 30, co-authored 37 publications receiving 7362 citations. Previous affiliations of Dolan B. Pritchett include Children's Hospital of Philadelphia & Heidelberg University.
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Journal ArticleDOI
Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology.
Dolan B. Pritchett,Harald Sontheimer,Brenda D. Shivers,Sanie Ymer,Helmut Kettenmann,Peter R. Schofield,Peter H. Seeburg +6 more
TL;DR: The isolation of a cloned cDNA encoding a new GABAA receptor subunit, termed γ2, which shares approximately 40% sequence identity with α-and β-subunits and whose messenger RNA is prominently localized in neuronal subpopulations throughout the CNS.
Journal ArticleDOI
Type I and type II GABAA-benzodiazepine receptors produced in transfected cells
TL;DR: Diversity in benzodiazepine pharmacology is generated by heterogeneity of the alpha subunit of the GABAA receptor, indicating that there are subtypes within the type II class.
Journal ArticleDOI
The dopamine D2 receptor: two molecular forms generated by alternative splicing.
R. Dal Toso,Bernd Sommer,M. Ewert,A. Herb,Dolan B. Pritchett,Bach Alfred,Brenda D. Shivers,Peter H. Seeburg +7 more
TL;DR: Results from polymerase chain reactions as well as in situ hybridization revealed that mRNA encoding both receptor forms is present in pituitary and brain of both rat and man, and the two receptor forms are generated by differential splicing possibly to permit coupling to different G proteins.
Journal ArticleDOI
Neurosteroids act on recombinant human GABAA receptors
Giulia Puia,Mariarita Santi,Stefano Vicini,Dolan B. Pritchett,Robert H. Purdy,Steven M. Paul,Peter H. Seeburg,Erminio Costa +7 more
TL;DR: An examination of single-channel currents recorded from outside-out patches excised from these transfected cells suggests that despite the common minimal structural requirements for expressing steroid and barbiturate actions, the mechanism of GABAA receptor modulation by these pregnane steroids may differ from that of barbiturates.
Journal ArticleDOI
Cerebellar GABAA receptor selective for a behavioural alcohol antagonist
Hartmut Lüddens,Dolan B. Pritchett,Dolan B. Pritchett,Martin Köhler,Iris Killisch,Kari Keinänen,Hannah Monyer,Rolf Sprengel,Peter H. Seeburg +8 more
TL;DR: In this article, a novel α-subunit (α6) of cerebellar granule cells was found to have high affinity to the GABA agonistmuscimol and the benzodiazepine Rol5-4513 (ref. 17), an antagonist of alcohol-induced motor incoordination and ataxia.