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Bernd Sommer
Researcher at Novartis
Publications - 56
Citations - 12895
Bernd Sommer is an academic researcher from Novartis. The author has contributed to research in topics: Amyloid precursor protein & AMPA receptor. The author has an hindex of 35, co-authored 56 publications receiving 12499 citations. Previous affiliations of Bernd Sommer include Boehringer Ingelheim & Heidelberg University.
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Journal ArticleDOI
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
Christine Sturchler-Pierrat,Dorothee Abramowski,Mairead Duke,Karl-Heinz Wiederhold,Claudia Mistl,Sabin Rothacher,Birgit Ledermann,Kurt Bürki,Peter Frey,Paolo Paganetti,Caroline Waridel,Michael E. Calhoun,Mathias Jucker,Alphonse Probst,Matthias Staufenbiel,Bernd Sommer +15 more
TL;DR: These mice resemble major features of AD pathology and suggest a central role of A beta in the pathogenesis of the disease.
Journal ArticleDOI
RNA editing in brain controls a determinant of ion flow in glutamate-gated channels.
TL;DR: It is shown that the genomic DNA sequences encoding the particular channel segment of all subunits harbor a glutamine codon (CAG), even though an arginine codon is found in mRNAs of three subunits.
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A family of AMPA-selective glutamate receptors
Kari Keinänen,William Wisden,Bernd Sommer,Pia Werner,Anne Herb,Todd A. Verdoorn,Bert Sakmann,Peter H. Seeburg +7 more
TL;DR: Four cloned cDNAs encoding 900-amino acid putative glutamate receptors with approximately 70 percent sequence identity were isolated from a rat brain cDNA library and in situ hybridization revealed differential expression patterns of the cognate mRNAs throughout the brain.
Journal ArticleDOI
Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS
Bernd Sommer,Kari Keinänen,Todd A. Verdoorn,William Wisden,Nail Burnashev,Anne Herb,Martin Köhler,Tamaki Takagi,Bert Sakmann,Peter H. Seeburg +9 more
TL;DR: These results identify a switch in the molecular and functional properties of glutamate receptors operated by alternative splicing.
Journal ArticleDOI
Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning.
Daniel Zamanillo,Rolf Sprengel,Øivind Hvalby,Vidar Jensen,Nail Burnashev,Andrej Rozov,Katharina Kaiser,Helmut Joachim Köster,Thilo Borchardt,Paul F. Worley,Joachim H. R. Lübke,Michael Frotscher,Peter H. Kelly,Bernd Sommer,Per Andersen,Peter H. Seeburg,Bert Sakmann +16 more
TL;DR: The results suggest that CA1 hippocampal LTP is controlled by the number or subunit composition of AMPA receptors and show a dichotomy between LTP in CA1 and acquisition of spatial memory.