Dolores Fregona

TL;DR: Gold(III) derivatives of N,N-dimethyldithiocarbamate and ethylsarcosinedithiOCarbamate have been proved to be much more cytotoxic in vitro than cisplatin, with IC50 values about 1- to 4-fold lower than that of the reference drug, even toward human tumor cell lines intrinsically resistant to cis platin itself.

TL;DR: The proteasome is revealed as a primary target for gold(III) dithiocarbamates and support the idea for their potential use as anticancer therapeutics.

TL;DR: These gold(III) complexes show high reactivity toward some biologically important isolated macromolecules, resulting in a dramatic inhibition of both DNA and RNA synthesis and inducing DNA lesions with a faster kinetics than cisplatin, suggesting that intracellular DNA might not represent their primary or exclusive biological target.

TL;DR: Experimental results show [Pd(MSDT)X]n (MSDT = methylsarcosinedithiocarbamate; X = Cl, Br) complexes show a strong dose-dependent growth inhibition of both HL60 and HeLa cells, with IC(50) values slightly higher than those recorded for cisplatin.

TL;DR: The results conclusively qualify gold(III) compounds as a promising class of cytotoxic agents, of outstanding interest for cancer treatment, while providing initial insight into their modes of action.