D
Dominique Scherer
Researcher at Heidelberg University
Publications - 30
Citations - 569
Dominique Scherer is an academic researcher from Heidelberg University. The author has contributed to research in topics: Colorectal cancer & Population. The author has an hindex of 11, co-authored 30 publications receiving 353 citations. Previous affiliations of Dominique Scherer include University Hospital Heidelberg & German Cancer Research Center.
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Journal ArticleDOI
Signals from the Adipose Microenvironment and the Obesity-Cancer Link-A Systematic Review.
Caroline Himbert,Caroline Himbert,Mahmoud Delphan,Mahmoud Delphan,Dominique Scherer,Laura W. Bowers,Stephen D. Hursting,Cornelia M. Ulrich,Cornelia M. Ulrich +8 more
TL;DR: Findings from these clinical studies reinforce preclinical data and suggest organ-dependent crosstalk between adipose tissue and carcinomas via VEGF, IL6, TNFα, and other mechanisms may lead to new targets and strategies for decreasing the burden of obesity-related cancers.
Journal ArticleDOI
Smoking is associated with hypermethylation of the APC 1A promoter in colorectal cancer: the ColoCare Study
Timothy M. Barrow,Hagen Klett,Hagen Klett,Reka Toth,Jürgen Böhm,Biljana Gigic,Nina Habermann,Dominique Scherer,Dominique Scherer,Petra Schrotz-King,Stephanie Skender,Clare Abbenhardt-Martin,Lin Zielske,Martin F. Schneider,Alexis Ulrich,Peter Schirmacher,Esther Herpel,Hermann Brenner,Hauke Busch,Hauke Busch,Melanie Boerries,Melanie Boerries,Cornelia M. Ulrich,Cornelia M. Ulrich,Karin B. Michels,Karin B. Michels +25 more
TL;DR: Experimental evidence is provided for hypermethylation of the key tumour suppressor gene APC being implicated in smoking‐associated colorectal carcinogenesis and significant hypomethylation of four loci associated with the TNXB gene in tissue from active smokers.
Journal ArticleDOI
Associations Between Dietary Patterns and Longitudinal Quality of Life Changes in Colorectal Cancer Patients: The ColoCare Study.
Biljana Gigic,Heiner Boeing,Reka Toth,Jürgen Böhm,Nina Habermann,Dominique Scherer,Petra Schrotz-King,Clare Abbenhardt-Martin,Stephanie Skender,Hermann Brenner,Jenny Chang-Claude,Michael Hoffmeister,Karen L. Syrjala,Paul B. Jacobsen,Martin F. Schneider,Alexis Ulrich,Cornelia M. Ulrich +16 more
TL;DR: A “Western” dietary pattern after surgery is inversely associated withQoL in CRC patients, whereas a diet rich in fruits and vegetables may be beneficial for patients' QoL over time.
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Interaction between polymorphisms in aspirin metabolic pathways, regular aspirin use and colorectal cancer risk: A case-control study in unselected white European populations.
Harsh Sheth,Harsh Sheth,Emma Northwood,Cornelia M. Ulrich,Dominique Scherer,Faye Elliott,Jennifer H. Barrett,David Forman,C. Roland Wolf,Gillian Smith,Michael S. Jackson,Mauro Santibanez-Koref,Robert W. Haile,Graham Casey,Mark A. Jenkins,Aung Ko Win,John L. Hopper,Loic Le Marchand,Noralane M. Lindor,Stephen N. Thibodeau,John D. Potter,John Burn,D. Timothy Bishop +22 more
TL;DR: A meta-analysis using two large population-based case-control datasets to assess 42 candidate SNPs in 15 genes whose association with colorectal cancer risk was putatively modified by aspirin use indicated no evidence of GxE interaction between genetic variants in genes involved in aspirin pathways, regular aspirin use and colon cancer risk.
Journal ArticleDOI
High Accumulation of Metformin in Colonic Tissue of Subjects With Diabetes or the Metabolic Syndrome.
Laura Paleari,Jürgen Burhenne,Johanna Weiss,Sebastian Foersch,Wilfried Roth,Andrea Parodi,Michael Gnant,Thomas Bachleitner-Hofmann,Dominique Scherer,Cornelia M. Ulrich,Borut Štabuc,Matteo Puntoni,Gianni Coccia,Marilena Petrera,Walter E. Haefeli,Andrea Decensi +15 more
TL;DR: A pilot study in 12 subjects with diabetes or the metabolic syndrome to compare metformin concentrations in plasma with colonic tissue according to colon site and found that the gut as an important site of action is recognized.