M
Michael Hoffmeister
Researcher at German Cancer Research Center
Publications - 449
Citations - 19395
Michael Hoffmeister is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Colorectal cancer & Population. The author has an hindex of 57, co-authored 377 publications receiving 14304 citations. Previous affiliations of Michael Hoffmeister include Leiden University & Heidelberg University.
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Journal ArticleDOI
Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer.
Jakob Nikolas Kather,Alexander T. Pearson,Niels Halama,Dirk Jäger,Jeremias Krause,Sven H. Loosen,Alexander Marx,Peter Boor,Frank Tacke,Ulf P. Neumann,Heike I. Grabsch,Heike I. Grabsch,Takaki Yoshikawa,Hermann Brenner,Jenny Chang-Claude,Jenny Chang-Claude,Michael Hoffmeister,Christian Trautwein,Tom Luedde +18 more
TL;DR: It is shown that deep residual learning can predict MSI directly from H&E histology, which is ubiquitously available and has the potential to provide immunotherapy to a much broader subset of patients with gastrointestinal cancer.
Journal ArticleDOI
Protection From Colorectal Cancer After Colonoscopy: A Population-Based, Case–Control Study
Hermann Brenner,Jenny Chang-Claude,Christoph M. Seiler,Alexander Rickert,Michael Hoffmeister +4 more
TL;DR: In this paper, the authors assessed the association between previous colonoscopy and risk for colorectal cancer (CRC) in a population-based case-control study.
Journal ArticleDOI
Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.
Albert Tenesa,Susan M. Farrington,James G. D. Prendergast,Mary Porteous,Marion F Walker,Naila Haq,Rebecca A. Barnetson,Evropi Theodoratou,Roseanne Cetnarskyj,Nicola Cartwright,Colin A. Semple,Andrew G. Clark,Fiona Reid,Lorna Smith,Kostas Kavoussanakis,Thibaud Koessler,Paul D.P. Pharoah,Stephan Buch,Clemens Schafmayer,Jürgen Tepel,Stefan Schreiber,Henry Völzke,Carsten Oliver Schmidt,Jochen Hampe,Jenny Chang-Claude,Michael Hoffmeister,Hermann Brenner,Stefan Wilkening,Federico Canzian,Gabriel Capellá,Victor Moreno,Ian J. Deary,John M. Starr,Ian Tomlinson,Zoe Kemp,Kimberley Howarth,Luis G. Carvajal-Carmona,Emily L. Webb,Peter Broderick,Jayaram Vijayakrishnan,Richard S. Houlston,Gad Rennert,Dennis G. Ballinger,Laura S. Rozek,Stephen B. Gruber,Koichi Matsuda,Tomohide Kidokoro,Yusuke Nakamura,Brent W. Zanke,Brent W. Zanke,Brent W. Zanke,Celia M. T. Greenwood,Celia M. T. Greenwood,Jagadish Rangrej,Jagadish Rangrej,Rafal Kustra,Alexandre Montpetit,Thomas J. Hudson,Thomas J. Hudson,Steven Gallinger,Steven Gallinger,Harry Campbell,Malcolm G. Dunlop +62 more
TL;DR: Findings extend the understanding of the role of common genetic variation in CRC etiology by identifying a previously unreported association, rs3802842 on 11q23, and carrying all six possible risk alleles yielded OR = 2.6 (95% CI = 1.75–3.89) for CRC.
Journal ArticleDOI
Effect of screening sigmoidoscopy and screening colonoscopy on colorectal cancer incidence and mortality: systematic review and meta-analysis of randomised controlled trials and observational studies.
TL;DR: Compelling and consistent evidence from randomised controlled trials and observational studies suggests that screening sigmoidoscopy and screening colonoscopy prevent most deaths from distal colorectal cancer.
Journal ArticleDOI
Protection From Right- and Left-Sided Colorectal Neoplasms After Colonoscopy: Population-Based Study
Hermann Brenner,Michael Hoffmeister,Volker Arndt,Christa Stegmaier,Lutz Altenhofen,Ulrike Haug +5 more
TL;DR: Prevalence of left- sided advanced colorectal neoplasms, but not right-sided advanced neoplasm, was strongly reduced within a 10-year period after colonoscopy, even in the community setting.