D
Dominique Talabot-Ayer
Researcher at University of Geneva
Publications - 36
Citations - 2737
Dominique Talabot-Ayer is an academic researcher from University of Geneva. The author has contributed to research in topics: Arthritis & Inflammation. The author has an hindex of 22, co-authored 33 publications receiving 2519 citations. Previous affiliations of Dominique Talabot-Ayer include Geneva College.
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Journal ArticleDOI
Leptin Signaling Deficiency Impairs Humoral and Cellular Immune Responses and Attenuates Experimental Arthritis
Nathalie Busso,Alexander So,Veronique Chobaz-Peclat,Carole Morard,Eduardo Martinez-Soria,Dominique Talabot-Ayer,Cem Gabay +6 more
TL;DR: It is observed that B lymphocytes express leptin receptor mRNA, indicating that in addition to its effect on the cellular response, leptin may exert a direct effect on B cell function.
Journal ArticleDOI
Inhibition of interleukin-33 signaling attenuates the severity of experimental arthritis.
Gaby Palmer,Dominique Talabot-Ayer,Céline Lamacchia,Dean Toy,Christian Alexander Seemayer,Sebastien Viatte,Axel Finckh,Dirk E. Smith,Cem Gabay +8 more
TL;DR: IL-33 is produced locally in inflamed joints, and neutralization of IL-33 signaling has a therapeutic effect on the course of arthritis, suggesting that locally produced IL- 33 may contribute to the pathogenesis of joint inflammation and destruction.
Journal ArticleDOI
Interleukin (IL)-33 induces the release of pro-inflammatory mediators by mast cells.
TL;DR: It is demonstrated for the first time that IL-33, a novel member of the IL-1 family of cytokines, stimulates the production of pro-inflammatory mediators by mast cells in addition to its effect on T helper 2 responses.
Journal ArticleDOI
IL-36R ligands are potent regulators of dendritic and T cells
Solenne Vigne,Gaby Palmer,Céline Lamacchia,Praxedis Martin,Dominique Talabot-Ayer,Emiliana Rodriguez,Francesca Ronchi,Frederica Sallusto,Huyen Dinh,John E. Sims,Cem Gabay +10 more
TL;DR: A critical role of IL-36R ligands in the interface between innate and adaptive immunity, leading to the stimulation of T helper responses is indicated.
Journal ArticleDOI
Interleukin-33 Is Biologically Active Independently of Caspase-1 Cleavage
TL;DR: Results clearly show that caspase-1 cleavage is not required for pro-IL-33 secretion and bioactivity, highlighting major differences between IL-1β and IL-33.