Francesca Ronchi

TL;DR: These findings demonstrate that by eliciting different cytokines C. albicans and S. aureus prime TH17 cells that produce either IFN-γ or IL-10, and identify IL-1β and IL-2 as pro- and anti-inflammatory regulators of TH17 Cells both at priming and in the effector phase.

TL;DR: It is demonstrated that antigen dose determines the size and duration of the Tfh cell response and GC reaction, the transient nature of theTfhcell phenotype is highlighted, and a link between overstimulation of TfH cells and the development of dysregulated humoral immune responses is suggested.

TL;DR: It is shown that the liver forms a second vascular barrier for eliminating commensal bacteria that have escaped from the gut, which may act as a functional vascular firewall that clears commensals that have penetrated either intestinal or systemic vascular circuits.

TL;DR: A critical role of IL-36R ligands in the interface between innate and adaptive immunity, leading to the stimulation of T helper responses is indicated.

TL;DR: The status of the knowledge and the open questions in the field focusing on the function of intestinal microbial metabolites or products on CNS cells during healthy and inflammatory conditions, such as multiple sclerosis, Alzheimer's and Parkinson’s diseases, and also neuropsychiatric disorders are discussed.