Donald A. Berry

TL;DR: Preliminary data suggest that the combination of IMC-A12 and temsirolimus is well tolerated and that it warrants further investigation, while the MTD has not been determined.

TL;DR: In this article, a randomized controlled trial was conducted to determine whether early induction and maintenance of hypothermia in patients with acute subdural hematoma (SDH) would lead to decreased ischemia-reperfusion injury and improve global neurologic outcome.

TL;DR: Multivariate analysis of gene expression signatures derived from pretreatment samples enabled the construction of models to predict achievement of pCR in TNBC, and these models performed well on the authors' test set, and will be assessed for their predictive ability in other TNBC data sets.

TL;DR: The authors in this article investigated the challenges of conducting an ongoing randomized study that evaluates molecular testing and targeted therapy (ClinicalTrials.gov: NCT02152254) and found that randomized controlled trials have been considered the gold standard for drug development, however, the execution of randomized trials in precision oncology in the advanced metastatic setting is complicated.

TL;DR: The MAESTRO trial randomized 693 locally advanced or metastatic pancreatic cancer patients to gemcitabine (G) + placebo vs G + evofosfamide (GE).