D
Donald A. Morrison
Researcher at University of Illinois at Chicago
Publications - 91
Citations - 9429
Donald A. Morrison is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: Gene & Transformation (genetics). The author has an hindex of 40, co-authored 89 publications receiving 8929 citations. Previous affiliations of Donald A. Morrison include University of Illinois at Urbana–Champaign & Unica Corporation.
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Journal ArticleDOI
Complete Genome Sequence of a Virulent Isolate of Streptococcus pneumoniae
Hervé Tettelin,Karen E. Nelson,Ian T. Paulsen,Jonathan A. Eisen,Timothy D. Read,Scott N. Peterson,John F. Heidelberg,Robert T. DeBoy,Daniel H. Haft,Robert J. Dodson,Anthony S. Durkin,Michelle L. Gwinn,James F. Kolonay,William C. Nelson,Jeremy Peterson,Lowell Umayam,Owen White,Steven L. Salzberg,Matthew R. Lewis,Diana Radune,Erik Holtzapple,Hoda Khouri,Alex M. Wolf,T. Utterback,Cheryl L. Hansen,Lisa McDonald,Tamara Feldblyum,Samuel V. Angiuoli,T. Dickinson,Erin Hickey,Ingeborg Holt,Brendan J. Loftus,Fan Yang,Hamilton O. Smith,J. C. Venter,Brian Dougherty,Donald A. Morrison,S. K. Hollingshead,Claire M. Fraser +38 more
TL;DR: A motif identified within the signal peptide of proteins is potentially involved in targeting these proteins to the cell surface of low–guanine/cytosine Gram-positive species.
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An unmodified heptadecapeptide pheromone induces competence for genetic transformation in Streptococcus pneumoniae
TL;DR: It is shown that strain CP1200 produces a 17-residue peptide that induces cells of the Streptococcus pneumoniae species to develop competence and the hypothesis is presented that this transport protein is encoded by comA, previously shown to be required for elaboration of the pneumococcal competence activator.
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Regulation of competence for genetic transformation in Streptococcus pneumoniae by an auto-induced peptide pheromone and a two-component regulatory system.
TL;DR: The authors showed that the competence regulation for genetic transformation in Streptococcus pneumoniae depends on a quorum-sensing system, but the only molecular elements of the system whose specific role have been identified are an extracellular peptide signal and an ABC-transporter required for its export.
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A highly conserved repeated DNA element located in the chromosome of Streptococcus pneumoniae.
Bernard Martin,Odile Humbert,Miguel Camara,Eric Guenzi,John Walker,Timothy J. Mitchell,Peter W. Andrew,Marc Prudhomme,Genevieve Alloing,Regine Hakenbeck,Donald A. Morrison,Graham J. Boulnois,Jean Pierre Claverys +12 more
TL;DR: A group of highly conserved DNA sequences located, in those cases studied, within intergenic regions of the chromosome of the Gram positive Streptococcus pneumoniae raises the intriguing possibility that BOX sequences are regulatory elements shared by several coordinately controlled genes, including competence-specific and virulence-related genes.
Journal ArticleDOI
An rpsL Cassette, Janus, for Gene Replacement through Negative Selection in Streptococcus pneumoniae
TL;DR: Replacement of the cassette by an arbitrary segment of DNA during a second transformation restored Sm resistance (and Kn sensitivity) and allowed construction of silent mutations and deletions or other gene replacements which lack a selectable phenotype.