Donald Dowbenko

TL;DR: Structural features of potential mammalian carbohydrate ligand(s) have not been well defined and data suggest that the sialyl Lewis(x) oligosaccharide may form the basis of a recognition domain common to all three selectins.

TL;DR: A tissue-specific mucin-like endothelial glycoprotein that appears to function as a scaffold that presents carbohydrates to the L-selectin lectin domain is defined.

TL;DR: Cl cloning of a murine cDNA that encodes the antigen recognized by the MEL-14 antibody shows that it contains a lectin domain that appears to be involved in the binding of lymphocytes to peripheral lymph node endothelium, thus defining a new type of cellular adhesion molecule.

TL;DR: A DNA sequence coding for the immunogenic capsid protein VP3 of foot-and-mouth disease virus A12 was ligated to a plasmid designed to express a chimeric protein from the Escherichia coli tryptophan promoter-operator system, which elicited high levels of neutralizing antibody and protection against challenge with foot- and- Mouth disease virus.

TL;DR: It is demonstrated that p21 is directly phosphorylated by AKT/PKB, a survival kinase that is hyperactivated in many late stage tumors and suggested that one mechanism of AKT-PKB regulation of tumor cell survival and/or proliferation is to stabilize p21 protein.